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Related Experiment Video

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Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies
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GENETIC AND EPIGENETIC CAUSES OF OBESITY.

Vidhu V Thaker1,2,3

  • 1Division of Molecular Genetics, Department of Pediatrics, Columbia University Medical Center, New York, NY.

Adolescent Medicine: State of the Art Reviews
|November 13, 2018
PubMed
Summary
This summary is machine-generated.

Obesity is a complex trait influenced by genes and environment. This review covers genetic causes, therapies, and the role of epigenetics in obesity intervention.

Keywords:
EpigeneticsGeneticsMonogenic obesityPersonalized medicineSevere early onset obesitySyndromic obesity

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Area of Science:

  • Genetics
  • Epigenetics
  • Metagenomics
  • Environmental Health

Background:

  • Obesity is a complex, heritable trait.
  • Genetics, epigenetics, metagenomics, and environment interact to influence obesity.
  • Severe early-onset obesity has identified numerous causative genes.

Purpose of the Study:

  • To review current knowledge on genetic causes of obesity.
  • To summarize available therapeutic options for obesity.
  • To discuss the role of epigenetics in mediating environmental influences on obesity.

Main Methods:

  • Literature review of genetic and epigenetic studies on obesity.
  • Analysis of diagnostic tools for genetic investigations.
  • Synthesis of current understanding of obesity's multifactorial etiology.

Main Results:

  • Numerous genes influencing obesity phenotype have been identified, particularly in early-onset severe cases.
  • Established genetic causes of obesity and potential therapeutic strategies are summarized.
  • Epigenetic modifications are highlighted as potential mediators of environmental factors.

Conclusions:

  • Genetic factors play a significant role in obesity, especially in severe early-onset forms.
  • Therapeutic options are evolving with genetic discoveries.
  • Epigenetics offers promising avenues for future obesity interventions by mediating environmental influences.