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Related Concept Videos

Genetic Screens02:46

Genetic Screens

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Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
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Incomplete Dominance01:43

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Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
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Genomic Imprinting and Inheritance02:30

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Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
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Skin Diseases and Disorders01:23

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Updated: Mar 18, 2026

Generation of Genetically Modified Organotypic Skin Cultures Using Devitalized Human Dermis
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Practice and Educational Gaps in Genodermatoses.

Julie V Schaffer1

  • 1Division of Pediatric Dermatology, Hackensack University Medical Center, 155 Polifly Road, Suite 101, Hackensack, NJ 07601, USA.

Dermatologic Clinics
|July 2, 2016
PubMed
Summary
This summary is machine-generated.

Recent advances in genodermatoses genetics offer new diagnostic and treatment insights. This article addresses integrating this genetic knowledge into clinical dermatology practice and education to improve patient care.

Keywords:
Genetic counselingGenetic testingGenodermatosesNext-generation sequencingPhenotype

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Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
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Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
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Area of Science:

  • Genetics and Molecular Biology
  • Dermatology
  • Medical Education

Background:

  • Significant progress in understanding the molecular basis of genodermatoses over the past two decades.
  • Expanded the intersection of dermatology and genetics, improving disease classification and revealing interconnections.
  • Existing genetic knowledge is not fully integrated into clinical practice or dermatology residency education.

Purpose of the Study:

  • To highlight strategies for overcoming barriers to integrating genetic knowledge into clinical dermatology.
  • To address educational gaps in genodermatoses for dermatology residents and practitioners.
  • To enhance dermatologists' capabilities in diagnosing, counseling, evaluating, and treating genodermatoses.

Main Methods:

  • Review and synthesis of recent advancements in genodermatoses genetics.
  • Identification of barriers in clinical practice and education.
  • Proposal of strategies to bridge the gap between genetic discoveries and dermatological application.

Main Results:

  • Molecular genetics has significantly advanced the understanding of genodermatoses.
  • Clinical and molecular data integration has refined disease classification and revealed relationships.
  • A gap persists in translating genetic knowledge into routine clinical practice and education.

Conclusions:

  • Implementing targeted strategies is crucial to integrate new genetic findings into dermatology.
  • Enhanced education and practice integration will improve patient outcomes for genodermatoses.
  • Dermatologists need updated skills to effectively manage patients with genetic skin disorders.