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Updated: Mar 18, 2026

Sex Stratified Neuronal Cultures to Study Ischemic Cell Death Pathways
Published on: December 9, 2013
Why the study of the effects of biological sex is important. Commentary
Georgios Kararigas1, Ute Seeland1, Maria Luisa Barcena de Arellano1
1Institute of Gender in Medicine (GiM), Center for Cardiovascular Research (CCR), Charité University, Hospital, Berlin, Germany - German Centre for Cardiovascular Research (DZHK), partner site Berlin, Germany.
Abstract:
Biological sex significantly affects the presentation, outcome of treatment and progression of disease. However, the role of sex has yet underestimated consequences for physiology and pathology. We put forward that a better understanding of the effects of sex in pathophysiology and the underlying mechanisms is necessary. This may facilitate the identification of targets that respond to specific therapies, thereby contributing towards a more appropriate and individualised medical care for both men and women.
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