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Disrupted Brain Connectivity Patterns in Patients with Type 2 Diabetes.
1From the Department of Radiology (Y.Cui, C.-Q.L., Y.Cai, C-X.W., G.-J.T.), Jiangsu Key Laboratory of Molecular and Functional Imaging, Zhongda Hospital, Medical School of Southeast University, Nanjing, China.
Type 2 diabetes alters brain connectivity, affecting cognitive functions like memory and executive performance. These changes in brain networks may explain the increased dementia risk associated with diabetes.
Area of Science:
- Neuroimaging
- Endocrinology
- Cognitive Neuroscience
Background:
- Type 2 diabetes (T2D) is linked to a higher risk of dementia.
- Understanding the neural underpinnings of cognitive decline in T2D is crucial.
Purpose of the Study:
- Investigate global brain connectivity patterns in individuals with T2D.
- Utilize resting-state functional magnetic resonance imaging (fMRI) to explore brain network alterations.
Main Methods:
- Compared functional brain connectivity in 40 T2D patients and 43 healthy controls using fMRI.
- Analyzed degree centrality and seed-based functional connectivity.
- Correlated connectivity changes with cognitive performance and diabetes metrics.
Main Results:
- T2D patients showed reduced connectivity in the left lingual gyrus (occipital network) and increased connectivity in the right insula and dorsal anterior cingulate cortex (salience network).
- Occipital hypoconnectivity correlated with impaired visual memory and executive function.
- Anterior cingulate cortex hyperconnectivity was linked to higher fasting glucose and better executive function.
Conclusions:
- Altered brain network connectivity is evident in T2D.
- These findings offer insights into the neural basis of cognitive impairment in type 2 diabetes.
- Suggests potential imaging biomarkers for diabetes-related cognitive decline.
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