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CURRENT STATUS OF DISULFIRAM THERAPY
P K Chakraborty1, H Singh2, K J Divinakumar3
1Ex Consultant (Psychiatry), Command Hospital, (Central Command), Lucknow-226 002.
Medical Journal, Armed Forces India
|July 2, 2016
Summary
Disulfiram
Area of Science:
- Pharmacology
- Addiction Medicine
- Clinical Therapeutics
Background:
- Disulfiram's effectiveness in Alcohol Dependence Syndrome relies on the disulfiram-ethanol reaction.
- Current disulfiram therapy requires structured aftercare due to adverse effects.
- High relapse rates occur after discontinuing disulfiram treatment.
Purpose of the Study:
- To evaluate the current clinical utility of disulfiram in Alcohol Dependence Syndrome.
- To analyze the impact of adverse effects and relapse rates on disulfiram's use.
- To review the necessity of supervised aftercare programs for disulfiram therapy.
Main Methods:
- Literature review on disulfiram efficacy and safety.
- Analysis of clinical guidelines and treatment protocols.
- Examination of relapse data associated with disulfiram discontinuation.
Main Results:
- Disulfiram's efficacy is contingent on the aversive disulfiram-ethanol reaction.
- Significant adverse effects necessitate supervised aftercare.
- Discontinuation of disulfiram therapy is strongly linked to high relapse rates.
Conclusions:
- Disulfiram therapy is less frequently employed due to its limitations.
- The need for structured aftercare and high relapse rates impact its clinical application.
- Alternative or adjunctive treatments may be preferred for Alcohol Dependence Syndrome.
Keywords:
Adverse drug reaction (ADR)Alcohol Dependence Syndrome (ADS)Disulfiram (Antabuse)Disulfiram-ethanol reaction (DER)More Related Videos
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