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Related Experiment Video

Updated: Mar 18, 2026

Use of Cerebral Open-Flow Microperfusion for the Longitudinal Collection of Interstitial Fluid in an Animal Model of Glioblastoma

Use of Cerebral Open-Flow Microperfusion for the Longitudinal Collection of Interstitial Fluid in an Animal Model of Glioblastoma

Published on: December 23, 2025

Lactate levels with glioblastoma multiforme.

Arunpreet Singh Kahlon¹, Mariam Alexander¹, Arundeep Kahlon¹

¹Departments of Medicine (A. S. Kahlon, Alexander, A. Kahlon) and Hematology/Oncology (Wright), State University New York-Upstate Medical University, Syracuse, New York.

Proceedings (Baylor University. Medical Center)

|July 2, 2016

Summary

Elevated lactate levels in a glioblastoma multiforme patient may indicate tumor-driven metabolic changes. This finding suggests lactate aids aggressive tumor progression and immune evasion.

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Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells

Published on: November 28, 2015

Area of Science:

Neuro-oncology
Cancer Metabolism
Oncologic Emergencies

Background:

Glioblastoma multiforme (GBM) is an aggressive primary brain tumor.
Deep vein thrombosis (DVT) can be a complication in cancer patients.
Lactic acidosis is a metabolic disturbance characterized by elevated lactate levels.

Observation:

A 37-year-old female patient with known GBM presented with new-onset DVT.
Elevated anion gap and plasma lactate levels were detected.
Brain MRI confirmed stable, advanced GBM; other causes of lactic acidosis were excluded.

Findings:

The patient's elevated lactate levels were attributed to the glioblastoma multiforme.
Tumor-produced lactate in the microenvironment is associated with metastasis.
Lactate production by tumors may facilitate immune evasion and resistance to radiation therapy.

Implications:

Elevated lactate may serve as a biomarker for aggressive tumor behavior in GBM.
Targeting tumor metabolism could be a therapeutic strategy for GBM.
Understanding lactate's role may inform novel approaches to overcome treatment resistance in glioblastoma.