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Intrarenal Injection of Escherichia coli in a Rat Model of Pyelonephritis
Published on: July 18, 2017
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Emphysematous pyelonephritis: A 10-year experience with 26 cases.
Raiz Ahmad Misgar1, Idrees Mubarik1, Arshad Iqbal Wani1
1Department of Endocrinology, Sher-I-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India.
Indian Journal of Endocrinology and Metabolism
|July 2, 2016
Summary
Emphysematous pyelonephritis (EPN), a severe kidney infection, often affects women with diabetes. Aggressive medical treatment is highly successful, with nephrectomy reserved for non-responsive cases.
Area of Science:
- Nephrology
- Infectious Diseases
- Urology
Background:
- Emphysematous pyelonephritis (EPN) is a necrotizing renal infection characterized by gas formation.
- Diabetes Mellitus (DM) is a significant comorbidity in most EPN cases.
- Early, aggressive medical management can potentially avert the need for nephrectomy.
Purpose of the Study:
- To analyze patient demographics, clinical presentation, and diagnostic findings in EPN.
- To investigate microbiological profiles and treatment modalities for EPN.
- To evaluate the influence of prognostic factors on treatment outcomes in EPN.
Main Methods:
- Retrospective review of 26 EPN patient hospital records.
- Assessment of clinical, laboratory, radiological, and microbiological data.
- Classification of EPN severity using the Huang system and evaluation of prognostic factors.
Main Results:
- All patients had DM; most were female.
- Over 60% had extensive EPN (Class 3 or 4) and 76.9% had multiple poor prognostic factors.
- Escherichia coli was the most common pathogen (50%); 88.5% responded to conservative treatment.
Conclusions:
- EPN predominantly affects women with DM, with E. coli as a frequent pathogen.
- Despite severe disease and poor prognostic factors, conservative treatment achieved an 88.5% success rate.
- Recommend aggressive medical treatment, reserving nephrectomy for non-improving or deteriorating patients.
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