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Fibronectin-Grafted Titanium Dental Implants: An In Vivo Study
Yu-Chi Chang1, Kuo-Ning Ho1, Sheng-Wei Feng1
1School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 110, Taiwan.
Biomed Research International
|July 2, 2016
Summary
Biologically modified titanium implants coated with fibronectin show enhanced bone integration and stability compared to argon-treated implants. This surface modification accelerates healing and offers clinical benefits for dental implants.
Area of Science:
- Biomaterials Science
- Dental Implantology
- Tissue Engineering
Background:
- Titanium surface modification using glow discharge plasma (GDP) and fibronectin coating improves physiochemical properties.
- Enhanced hydrophilicity, roughness, cell adhesion, migration, and proliferation are key benefits of surface modification.
Purpose of the Study:
- To evaluate the in vivo bone integration efficacy of biologically modified implant surfaces.
- To compare the bone integration of argon-treated GDP (Ar-GDP) implants with GDP-fibronectin (GDP-fib) implants.
Main Methods:
- In vivo study in beagle dogs using surface-modified implants in the mandibular premolar area for 2-8 weeks.
- Histologic evaluation, resonance frequency analysis (RFA), and microcomputed tomography (micro-CT) were used to assess implant stability and bone-implant contact.
Main Results:
- GDP-fib implants demonstrated significantly greater implant stability quotient values than Ar-GDP implants at 2 and 4 weeks.
- Micro-CT revealed a higher bone volume/total volume ratio for GDP-fib implants.
- Histological analysis confirmed enhanced bone formation and osseointegration around GDP-fib implants.
Conclusions:
- Biologically modified implant surfaces (GDP-fib) significantly enhance bone integration and implant stability.
- The observed enhancement in stability is supported by RFA, micro-CT, and histological findings.
- This improved stability suggests faster healing and potential clinical benefits for dental implant treatments.
