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Portable, Constriction-Expansion Blood Plasma Separation and Polymerization-Based Malaria Detection.

Tatyana A Shatova1, Shefali Lathwal1, Marissa R Engle1

  • 1Department of Chemical Engineering, Massachusetts Institute of Technology , 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.

Analytical Chemistry
|July 2, 2016
PubMed
Summary

A novel portable microfluidic device achieves 100% pure plasma separation from undiluted blood with high yield. This portable blood plasma separation technology enhances diagnostic accuracy for diseases like malaria.

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Area of Science:

  • Biomedical Engineering
  • Microfluidics
  • Point-of-Care Diagnostics

Background:

  • Accurate and efficient blood plasma separation is crucial for various diagnostic assays.
  • Existing passive separation methods often suffer from low purity and yield.
  • The need for portable, user-friendly separation devices for field diagnostics is increasing.

Purpose of the Study:

  • To develop and present a portable, microfluidic device for high-purity blood plasma separation.
  • To evaluate the device's performance in terms of purity, yield, and flow rate.
  • To demonstrate the device's utility in a point-of-care diagnostic application.

Main Methods:

  • A microfluidic device with a constriction-expansion design was fabricated.
  • The device was tested with undiluted whole blood to assess plasma separation efficiency.
  • Performance metrics including purity, yield, and flow rate were quantified.
  • The device was integrated with a paper-based diagnostic test for malaria detection.

Main Results:

  • The device achieved 100.0% plasma purity with a 9% yield from undiluted blood.
  • Purity levels were an order of magnitude higher than previous passive separation techniques.
  • High flow rates (5-30 μL/min) were maintained with minimal clogging and biofouling.
  • Integration with a malaria diagnostic test showed amplified color change below clinical relevancy.

Conclusions:

  • The portable microfluidic device offers a significant advancement in blood plasma separation technology.
  • Its high purity, yield, and portability make it suitable for point-of-care diagnostics.
  • The device demonstrates potential for improving early disease detection, such as malaria.
  • This technology can be readily integrated with existing microfluidic and laboratory diagnostic platforms.