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Glycerin Suppositories Use in Very Low Birth Weight Infants

Shalinkumar Patel1, Narendra Dereddy1, Ajay J Talati1

  • 1Division of Neonatology, Department of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee.

American Journal of Perinatology
|July 2, 2016
PubMed

Insights

Glycerin suppositories (GS) use in very low birth weight (VLBW) infants was associated with longer hospital stays and delayed enteral feeding. Further research is needed to confirm safety and efficacy in this vulnerable population.

Area of Science:

  • Neonatalogy
  • Pediatric Gastroenterology

Background:

  • Very low birth weight (VLBW) infants often experience gastrointestinal issues.
  • Glycerin suppositories (GS) are commonly used in neonatal intensive care units (NICUs).

Purpose of the Study:

  • To investigate the characteristics of VLBW infants receiving GS.
  • To evaluate the association between GS use and clinical outcomes in VLBW infants.

Main Methods:

  • Retrospective study of 1,073 VLBW infants (500-1,499g) admitted to a level III NICU.
  • Comparison of outcomes between infants who received GS and those who did not.
  • Multivariate analyses controlling for gestational age and small for gestational age status.

Main Results:

  • Nearly half of VLBW infants (49.1%) received GS.
  • No significant difference in necrotizing enterocolitis incidence between groups.
  • GS group showed significantly longer time to full enteral feeds and hospital stay.

Conclusions:

  • Frequent GS use in VLBW infants is associated with prolonged enteral feeding and hospitalization.
  • GS may serve as a marker for gastrointestinal dysmotility, indicating potential unfavorable outcomes.
  • Prospective studies are warranted to assess the safety and efficacy of GS in VLBW infants.

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