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Update on local allergic rhinitis.

Niyazi Altıntoprak1, Murat Kar2, Nuray Bayar Muluk3

  • 1Tuzla State Hospital, ENT Clinics, Istanbul, Turkey.

International Journal of Pediatric Otorhinolaryngology
|July 3, 2016
PubMed
Summary
This summary is machine-generated.

Local Allergic Rhinitis (LAR) is a localized nasal allergic response without systemic atopy. This review updates its definition, diagnosis, and treatment, highlighting key research areas.

Keywords:
AbsenceAntibodiesLocal allergic rhinitisLocal productionMechanismSpecific IgESystemic atopy

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Area of Science:

  • Allergy and Immunology
  • Otorhinolaryngology

Background:

  • Local Allergic Rhinitis (LAR) is a distinct allergic condition.
  • It is characterized by a localized nasal allergic response without systemic atopy.

Purpose of the Study:

  • To provide an updated review of the literature on Local Allergic Rhinitis (LAR).
  • To cover updated definitions, classifications, mechanisms, comorbidities, and recommendations for diagnosis and treatment.
  • To identify areas for future research in LAR.

Main Methods:

  • Literature review of existing studies on Local Allergic Rhinitis (LAR).

Main Results:

  • LAR involves local production of specific IgE (sIgE) antibodies.
  • It features a TH2 mucosal cell infiltration during allergen exposure.
  • A positive nasal allergen provocation test and mediator release are key characteristics.

Conclusions:

  • This review consolidates current knowledge on Local Allergic Rhinitis (LAR).
  • It emphasizes the importance of LAR in allergy research.
  • Further evidence-based studies are needed in defined research areas.