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Related Experiment Videos

Cardiac autonomic dysfunction in obese subjects.

M Rossi1, G Marti, L Ricordi

  • 1Department of Internal Medicine, IRCCS Policlinico San Matteo, University of Pavia, Italy.

Clinical Science (London, England : 1979)
|June 1, 1989
PubMed
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Obese individuals show significant alterations in cardiac autonomic function, particularly affecting parasympathetic pathways. These findings highlight the impact of obesity on cardiovascular health and autonomic nervous system regulation.

Area of Science:

  • Cardiology
  • Autonomic Nervous System Physiology
  • Metabolic Disorders

Background:

  • Obesity is associated with increased cardiovascular risk.
  • Cardiac autonomic dysfunction is a potential complication of obesity.
  • Standardized tests can evaluate autonomic function.

Purpose of the Study:

  • To evaluate cardiac autonomic alterations in obese subjects.
  • To compare autonomic function between obese individuals and controls.
  • To assess the prevalence of autonomic dysfunction in obesity.

Main Methods:

  • Assessed cardiac autonomic function using four standard tests: heart rate response to deep breathing, Valsalva maneuver, systolic blood pressure fall after standing, and diastolic pressure rise during handgrip.
  • Employed a novel cross-correlation test for computerized analysis of respiratory sinus arrhythmia via spectral analysis of electrocardiographic and respiratory signals.

Related Experiment Videos

  • Compared results between 23 obese subjects (BMI 37.2 +/- 3.03 kg/m2) and 78 controls (BMI 22.5 +/- 2.6 kg/m2).

    • Main Results:

    • Obese subjects exhibited significantly lower parasympathetic function indicated by heart rate response to deep breathing (13.95 +/- 8.65 vs 24.5 +/- 7.65 beats/min, P < 0.001) and the cross-correlation test (4.28 +/- 0.74 vs 5.14 +/- 0.63 units, P < 0.001).
    • Abnormalities in deep breathing response or cross-correlation were observed in 43.5% of obese subjects.
    • No significant differences in sympathetic function tests or Valsalva maneuver response were found between obese and control groups.

    Conclusions:

    • Obesity is linked to significant impairments in cardiac autonomic function, specifically affecting parasympathetic activity.
    • The deep breathing test and cross-correlation analysis are sensitive indicators of autonomic dysfunction in obese individuals.
    • Further research is warranted to explore the long-term cardiovascular implications of autonomic alterations in obesity.