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Inhibitory effect of alpha-mangostin on Candida biofilms

Ruchadaporn Kaomongkolgit1, Kusuma Jamdee2

  • 1Department of Oral Diagnosis, Faculty of Dentistry, Naresuan University, Phitsanulok, 65000, Thailand. ruchadapornk@nu.ac.th.

Odontology
|July 3, 2016
PubMed

Keywords:
Alpha-mangostinAnti-biofilmCandida species

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Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to...
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