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Updated: Mar 31, 2026
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Dual-Loaded Galangal Extract and Lemongrass Oil Biobased Self-Emulsifying System for Denture-Cleansing Applications
Premnapa Sisopa1,2, Supaporn Lamlertthon3,4, Ruchadaporn Kaomongkolgit5
1Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok 65000, Thailand.
ACS Omega
|March 30, 2026
Summary
A novel plant-based denture cleanser powder, combining galangal extract and lemongrass oil in a solid self-emulsifying system, effectively combats denture stomatitis and Candida albicans. This natural alternative shows promise for oral health.
Area of Science:
- Materials Science
- Pharmacology
- Mycology
Background:
- Denture stomatitis, linked to denture plaque, poses challenges for wearers.
- Commercial denture cleansers may have drawbacks, including adverse health effects and altered denture color.
- A need exists for effective, natural alternatives to prevent denture-related oral inflammation.
Purpose of the Study:
- To develop and characterize a novel dual-loaded galangal extract (GE) and lemongrass oil (LGO) solid self-emulsifying drug delivery system (solid-SEDDS-GL) as a natural denture cleanser powder.
- To evaluate the physicochemical properties, antifungal efficacy, effect on denture color, and stability of the developed formulation.
Main Methods:
- Gas chromatography-mass spectrometry (GC-MS) identified key compounds: 1'-acetoxychavicol acetate (ACA) in GE and citral in LGO.
- Formulation of solid-SEDDS-GL and assessment of moisture content, emulsification time, particle size, and pH.
- High-performance liquid chromatography (HPLC) determined encapsulation efficiency; antifungal activity against Candida albicans was tested using MIC and MFC assays; fungal adhesion and color stability were evaluated.
Main Results:
- The solid-SEDDS-GL formulation exhibited favorable properties: low moisture (<10%), rapid emulsification (<2 min), small particle size (<100 nm), and mildly acidic pH (∼5.0).
- High encapsulation efficiency (>80%) for ACA and citral was achieved.
- The formulation demonstrated potent antifungal activity, eradicating C. albicans within 60 min, reducing fungal adhesion by over 90%, and preserving denture color. Stability was confirmed for at least 6 months.
Conclusions:
- The developed dual-loaded solid-SEDDS-GL denture cleanser powder effectively inhibits Candida albicans and reduces fungal adhesion.
- This plant-based formulation offers a promising, stable alternative to conventional denture cleansers for preventing denture stomatitis.
- The formulation maintains denture color integrity, addressing a limitation of some commercial products.
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