Solubility-Enhanced α‑Mangostin Bilayer Films: Synergizing Mucoadhesion and Protection for Effective Aphthous Ulcer...

Area of Science:

• Pharmacology
• Materials Science
• Oral Medicine

Background:

• Aphthous ulcers cause significant pain and reduce quality of life.
• α-Mangostin, a mangosteen compound, has anti-inflammatory effects but poor solubility.
• Localized treatments are needed for effective aphthous ulcer management.

Purpose of the Study:

• To develop a double-layer mucoadhesive film for enhanced α-mangostin delivery.
• To improve α-mangostin solubility and provide dual protection and therapy.
• To create a promising formulation for aphthous ulcer treatment.

Main Methods:

• Formulated α-mangostin solid dispersions (MPESD) using PVP K30.
• Fabricated double-layer mucoadhesive films via solvent casting (ethylcellulose and gelatin-HPMC).
• Evaluated film mechanical properties, wettability, residence time, and drug release.

Main Results:

• MPESD significantly increased α-mangostin solubility to 8.12 mg/mL.
• Films exhibited suitable mechanical strength (1.63 N/mm²) and flexibility (20% elongation).
• Optimized films showed >8 h in vitro residence time and 96% drug release within 2 h.

Conclusions:

• The double-layer mucoadhesive film effectively enhances α-mangostin solubility and delivery.
• This formulation offers a promising strategy for localized aphthous ulcer management.
• The developed film provides dual protection and therapeutic benefits for oral lesions.