Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inhibitors of Gram-positive Cell Wall Synthesis01:23

Inhibitors of Gram-positive Cell Wall Synthesis

8
Bacterial cell walls are typically rigid structures composed mainly of peptidoglycan, a mesh-like polymer that provides mechanical strength and maintains cell shape. The synthesis of peptidoglycan is a crucial process in bacterial growth and serves as a primary target for many antibiotics.Mechanism of Action of Beta-Lactam AntibioticsBeta-lactam antibiotics, such as penicillin, inhibit peptidoglycan synthesis in actively growing cells. These antibiotics share a characteristic four-membered...
8
Inhibitors of Bacterial Protein Synthesis01:25

Inhibitors of Bacterial Protein Synthesis

14
Aminoglycosides constitute a highly potent class of bactericidal antibiotics that exert their antimicrobial effects by targeting the bacterial ribosome, specifically disrupting protein synthesis. These polycationic molecules consist of amino-modified sugars linked via glycosidic bonds to an aminocyclitol core such as 2-deoxystreptamine or streptamine. Their strong positive charges facilitate tight binding to the negatively charged phosphate backbone of ribosomal RNA (rRNA), primarily at the 16S...
14
Antimicrobial Proteins01:23

Antimicrobial Proteins

15.2K
Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
15.2K
Combined Effects of Drugs: Synergism01:27

Combined Effects of Drugs: Synergism

7.2K
Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
7.2K
Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

7
Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within...
7
Development of Antibiotic Resistance01:30

Development of Antibiotic Resistance

1.9K
Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
1.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Time Spent in Rural Placements and Working Rurally After Graduation: A Retrospective Cohort Study of University of Adelaide Medical Graduates, 2010-2021.

The Australian journal of rural health·2026
Same author

Management and outcomes of ocular surface squamous neoplasia at a tertiary hospital, South Africa.

Eye (London, England)·2026
Same author

Correction: Management and outcomes of ocular surface squamous neoplasia at a tertiary hospital, South Africa.

Eye (London, England)·2026
Same author

A national survey of dementia diagnosis and care in English memory services.

BMC geriatrics·2026
Same author

Public Health.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same author

Suicide Risk and Protective Factors in Nursing Students in the United States.

Journal of advanced nursing·2025
Same journal

Compassion fatigue among critical care nurses: a literature review.

Nursing management (Harrow, London, England : 1994)·2026
Same journal

Repositioning entrepreneurial competence as a core nursing capability: unlocking nurses' leadership and innovation potential.

Nursing management (Harrow, London, England : 1994)·2026
Same journal

How to design and deliver a nurse fellowship.

Nursing management (Harrow, London, England : 1994)·2026
Same journal

Relationship between leadership transparency and workplace cynicism among nurses: a systematic review and meta-analysis.

Nursing management (Harrow, London, England : 1994)·2026
Same journal

Strengthening nurses' recognition of, and response to, domestic violence and abuse.

Nursing management (Harrow, London, England : 1994)·2026
Same journal

From strain to strength: enhancing the benefits of employing temporary nurses.

Nursing management (Harrow, London, England : 1994)·2026
See all related articles

Related Experiment Video

Updated: Mar 18, 2026

A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment
12:58

A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment

Published on: May 25, 2017

9.5K

Action on antibiotics.

Susan Williams1

  • 1RCN.

Nursing Management (Harrow, London, England : 1994)
|July 3, 2016
PubMed
Summary
This summary is machine-generated.

Antimicrobial resistance (AMR) is a global threat demanding immediate action across healthcare, pharmaceuticals, farming, and public sectors. Addressing AMR requires a coordinated, multi-sectoral approach to mitigate its widespread impact.

More Related Videos

Stress-induced Antibiotic Susceptibility Testing on a Chip
12:41

Stress-induced Antibiotic Susceptibility Testing on a Chip

Published on: January 8, 2014

7.0K
Quantification of Violacein in Chromobacterium violaceum and Its Inhibition by Bioactive Compounds
07:13

Quantification of Violacein in Chromobacterium violaceum and Its Inhibition by Bioactive Compounds

Published on: August 8, 2025

1.9K

Related Experiment Videos

Last Updated: Mar 18, 2026

A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment
12:58

A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment

Published on: May 25, 2017

9.5K
Stress-induced Antibiotic Susceptibility Testing on a Chip
12:41

Stress-induced Antibiotic Susceptibility Testing on a Chip

Published on: January 8, 2014

7.0K
Quantification of Violacein in Chromobacterium violaceum and Its Inhibition by Bioactive Compounds
07:13

Quantification of Violacein in Chromobacterium violaceum and Its Inhibition by Bioactive Compounds

Published on: August 8, 2025

1.9K

Area of Science:

  • Public Health
  • Infectious Diseases
  • One Health

Background:

  • Antimicrobial resistance (AMR) is a significant global health challenge.
  • The threat of AMR extends beyond clinical settings, impacting various sectors.
  • International consensus recognizes the urgent need for comprehensive AMR action.

Purpose of the Study:

  • To highlight the broad scope of antimicrobial resistance (AMR).
  • To emphasize the necessity of multi-sectoral engagement in combating AMR.
  • To underscore the global call for immediate action against AMR.

Main Methods:

  • This study is a review of international perspectives on antimicrobial resistance.
  • It synthesizes current understanding of AMR's impact across different domains.
  • Analysis of global discourse on AMR strategies and interventions.

Main Results:

  • Widespread international acknowledgment of antimicrobial resistance as a critical issue.
  • Identification of key sectors involved: healthcare, pharmaceuticals, farming, and the public.
  • Recognition of the interconnectedness of AMR issues across these sectors.

Conclusions:

  • Urgent, coordinated action is required globally to address antimicrobial resistance.
  • Effective AMR strategies must involve collaboration between healthcare, industry, agriculture, and the public.
  • A unified approach is essential to mitigate the growing threat of antimicrobial resistance.