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Online Repetitive Transcranial Magnetic Stimulation of Dorsomedial and Dorsolateral Prefrontal Cortex in Cognition Decision Making, and Cognitive Dissonance

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Chemogenetic approach to model hypofrontality.

Ike Dela Peña¹, Wei-Xing Shi²

¹Department of Pharmaceutical and Administrative Sciences, Loma Linda University School of Pharmacy, Loma Linda, CA 92350, USA.

Medical Hypotheses

|July 4, 2016

Summary

This summary is machine-generated.

Designer receptors exclusively activated by designer drugs (DREADDs) offer a precise method to study prefrontal cortex (PFC) hypofunction in disorders like schizophrenia. This technique aids in understanding dopamine system changes and discovering new therapeutic targets.

Keywords:

Chemogenetics DREADDs Prefrontal cortex Schizophrenia

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Area of Science:

Neuroscience
Psychiatry
Pharmacology

Background:

Prefrontal cortex (PFC) hypofunction is implicated in schizophrenia, ADHD, and drug addiction.
Hypofrontality may cause negative/cognitive symptoms in schizophrenia and alter dopamine neuron activity, potentially leading to positive symptoms.
Previous methods for modeling PFC hypofunction have limitations.

Purpose of the Study:

To introduce designer receptors exclusively activated by designer drugs (DREADDs) as a precise tool to model PFC hypofunction.
To investigate the effects of PFC hypofunction on dopamine neuron activity using electrophysiology.
To explore DREADDs for drug target discovery in PFC-related disorders.

Main Methods:

Utilizing DREADDs chemogenetics to precisely manipulate PFC activity.
Employing electrophysiological recordings to monitor dopamine neuron activity.
Assessing the reversal of behavioral abnormalities by enhancing PFC activity.

Main Results:

DREADDs allow for precise interrogation of PFC functions and modeling of hypofrontality.
This approach enables investigation into the effects of PFC hypofunction on dopamine pathways.
DREADDs facilitate the exploration of therapeutic strategies targeting PFC dysfunction.

Conclusions:

DREADDs offer significant advantages over traditional methods for simulating PFC hypofunction.
This technique is valuable for both disease modeling and drug target discovery for PFC-related disorders.
Modulating PFC activity via DREADDs may reveal novel therapeutic targets for schizophrenia and related conditions.