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Methods for Detecting Cough and Airway Inflammation in Mice
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COGAN'S SYNDROME.

Daniela Adriana Iliescu, Cristina Mihaela Timaru, Mehdi Batras

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    |July 5, 2016
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    Cogan's syndrome is a rare autoimmune vasculitis with ocular and audiovestibular symptoms. While infection was once suspected, autoimmunity is now the leading hypothesis for its cause, with corticosteroids as a primary treatment.

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    Area of Science:

    • Rheumatology
    • Ophthalmology
    • Otolaryngology

    Background:

    • Cogan's syndrome is a rare autoimmune vasculitis.
    • It presents with ocular and audiovestibular symptoms, mimicking Meniere's syndrome.
    • Pathogenesis remains largely unknown, with autoimmunity now favored over infection.

    Purpose of the Study:

    • To review current knowledge on Cogan's syndrome.
    • To explore its etiology, diagnosis, and treatment options.

    Main Methods:

    • Systematic review of relevant publications.
    • Literature search from 1945 to 2014.

    Main Results:

    • Approximately 70% of patients exhibit systemic disease.
    • Vasculitis is identified as the pathological mechanism in systemic cases.
    • Corticosteroids are the established first-line treatment.

    Conclusions:

    • Cogan's syndrome is a rare autoimmune vasculitis with uncertain pathogenesis.
    • Autoimmunity is the current leading hypothesis.
    • Novel treatments like TNF-alpha blockers show promise but require further study.