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Murine Model of Thoracic Aortic Dissection Induced by Oral β-Aminopropionitrile and Subcutaneous Angiotensin II Infusion
Published on: May 16, 2025
Socioeconomic disparities affect survival after aortic dissection
Loay S Kabbani1, Sara Wasilenko1, Timothy J Nypaver1
1Division of Vascular Surgery, Henry Ford Hospital, Detroit, Mich.
Lower socioeconomic status (SES) is linked to worse survival outcomes for patients with aortic dissection. This includes both short-term and long-term survival rates, highlighting health disparities in cardiovascular care.
Area of Science:
- Cardiovascular Medicine
- Health Services Research
- Public Health
Background:
- Socioeconomic status (SES) is a known determinant of health outcomes across various diseases.
- However, its impact on aortic dissection, a critical cardiovascular emergency, remains understudied.
- Understanding SES-related disparities is crucial for equitable patient care.
Purpose of the Study:
- To investigate the association between socioeconomic status (SES) and survival rates in patients diagnosed with aortic dissection.
- To evaluate the impact of SES on both 30-day and long-term mortality following aortic dissection.
Main Methods:
- Utilized hospital discharge records to identify 212 patients with acute aortic dissection (118 Type A, 94 Type B).
- Assessed SES using the neighborhood deprivation index, derived from patient home addresses.
- Analyzed 30-day mortality and long-term survival via the Social Security Death Index, controlling for demographics and comorbidities.
Main Results:
- A higher neighborhood deprivation index (indicating lower SES) was significantly associated with reduced long-term survival (HR 1.43, P=.001) and increased 30-day mortality (HR 1.43, P=.02).
- Patients with Type B aortic dissections exhibited higher mean neighborhood deprivation index scores compared to those with Type A dissections (P=.029).
Conclusions:
- Lower socioeconomic status is a significant predictor of poorer short-term and long-term survival following aortic dissection.
- Patients with Type B aortic dissections are more likely to reside in socioeconomically disadvantaged neighborhoods.
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