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HPIDB 2.0: a curated database for host-pathogen interactions.

Mais G Ammari1, Cathy R Gresham2, Fiona M McCarthy1

  • 1School of Animal and Comparative Biomedical Sciences, University of Arizona, Tucson, AZ 85721, USA.

Database : the Journal of Biological Databases and Curation
|July 5, 2016
PubMed
Summary
This summary is machine-generated.

HPIDB 2.0 enhances the study of host-pathogen interactions (HPI) by providing a comprehensive, curated database. This resource aids researchers in understanding infectious diseases and developing new intervention strategies.

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Area of Science:

  • * Molecular biology and bioinformatics
  • * Infectious disease research
  • * Agricultural science

Background:

  • * Host-pathogen interactions (HPI) are crucial for understanding infectious diseases, but HPI data is scarce in existing databases, particularly for agricultural systems.
  • * Developing novel intervention strategies requires robust resources for annotating, predicting, and displaying HPI.
  • * Existing molecular interaction databases lack sufficient HPI data, necessitating specialized resources.

Purpose of the Study:

  • * To present the updated HPIDB 2.0, a comprehensive resource for host-pathogen interaction data.
  • * To detail the enhancements in data curation, integration, and accessibility for agricultural researchers.
  • * To improve the analysis and understanding of infectious diseases through a specialized HPI database.

Main Methods:

  • * Manual biocuration of molecular interaction data following International Molecular Exchange consortium standards.
  • * Integration of HPI data from external sources and inference of additional interactions.
  • * Enhancement of database interface with improved search, Gene Ontology functional information, and network visualization tools.

Main Results:

  • * HPIDB 2.0 contains 45,238 manually curated HPI entries, covering 594 pathogen and 70 host species.
  • * The database provides both manually curated and community annotations for HPI network analysis.
  • * Enhanced search functionality and network visualization tools facilitate data access and analysis.

Conclusions:

  • * HPIDB 2.0 offers the most comprehensive HPI data available, supporting research in infectious diseases, especially in agricultural contexts.
  • * The updated database and interface facilitate easier access and analysis of high-quality HPI data for researchers.
  • * Regularly updated, publicly available data promotes data sharing and advances the study of host-pathogen interactions.