Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Atherometric system: morphometric standardized methodology to study atherosclerosis and its consequences.

J E Fernández-Britto1, P V Carlevaro

  • 1Department of Pathology, Dr. C. J. Finlay Hospital, Faculty of Medicine Finlay-Albarran, Higher Institute of Medical Science of Havana, Cuba.

Gegenbaurs Morphologisches Jahrbuch
|January 1, 1989
PubMed
Summary

This study introduces the atherometric system (AS), a novel method for quantifying atherosclerosis severity using arterial and organ damage variables. The AS enables standardized morphometric analysis for disease investigation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pathomorphometrical characteristics of atherosclerosis in youth. A multinational investigation of WHO/World Heart Federation (1986-1996), using atherometric system.

Nutrition, metabolism, and cardiovascular diseases : NMCD·2000
Same author

Pathobiological determinants of atherosclerosis in youth (PBDAY Study), 1986-96.

Bulletin of the World Health Organization·1999
Same author

Atherosclerotic lesions, myocardial damage and lipidograms: a multiarterial study applying an atherometric system and canonical correlation.

General & diagnostic pathology·1998
Same author

Coronary atherosclerosis and chemical trace elements in the hair. A canonical correlation study of autopsy subjects, using an atherometric system and the X-ray fluorescence analysis.

Zentralblatt fur Pathologie·1993
Same author

Neurohistochemical and electron microscopic investigations of pathological and age-related changes in the cardiovascular system.

Acta histochemica. Supplementband·1992
Same author

Coronary atherosclerosis and hair elements contents. A correlation study of 102 autopsy subjects using the energy dispersive X-ray fluorescence analysis and applying an atherometric system.

Zentralblatt fur Pathologie·1992

Area of Science:

  • Cardiovascular Research
  • Medical Imaging
  • Biophysics

Background:

  • Atherosclerosis is a complex disease with significant consequences.
  • Standardized methods are needed to accurately characterize arterial and organ damage.

Purpose of the Study:

  • To introduce a novel standardized morphometric methodology, the atherometric system (AS).
  • To enable detailed pathomorphological, pathogenetic, statistical, and epidemiological investigations of atherosclerosis.

Main Methods:

  • Developed the atherometric system (AS) by integrating biophysical and mathematical analyses of arterial and organ-related variables.
  • Classified AS variables into descriptives (arterial lesions, organ damage volumes) and weighting indices (obstruction, stenosis, benignity).
  • Utilized a digitizer and personal computer for data acquisition, processed with SPSS statistical software.

Related Experiment Videos

Main Results:

  • The AS provides a 3-dimensional vector representation for different atherosclerotic lesion types (fatty streak, fibrous plaque, severe plaque).
  • Weighting indices derived from AS variables quantify atherosclerosis severity and organ damage.
  • The methodology allows for the analysis of fibrosis, necrosis, and hemorrhage in affected organs.

Conclusions:

  • The atherometric system (AS) offers a standardized and comprehensive approach to studying atherosclerosis.
  • AS facilitates in-depth investigations into the disease's characteristics, progression, and impact on organs.
  • This methodology supports advanced statistical and epidemiological research in cardiovascular disease.