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Related Concept Videos

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Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
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DGV: Dengue Genographic Viewer.

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  • 1Pathogen Genomics Center, National Institute of Infectious Diseases Tokyo, Japan.

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Summary
This summary is machine-generated.

A new Dengue Genographic Viewer (DGV) database tracks dengue virus (DENV) serotypes and genotypes globally. This tool aids in understanding DENV spread and planning control strategies for dengue infections.

Keywords:
NGSdengue virusgenographgenotypingweb service

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Area of Science:

  • Virology
  • Epidemiology
  • Bioinformatics

Background:

  • Dengue viruses (DENVs) and their vectors are prevalent in tropical and subtropical regions.
  • An autochthonous DENV case in Tokyo, Japan, in 2014 marked the first in 70 years, highlighting the need for robust surveillance.
  • Comprehensive DENV sequence and epidemiological data are essential for tracking outbreaks and enabling rapid responses.

Purpose of the Study:

  • To construct a comprehensive Dengue virus database integrating serotype, genotype, collection year, and geographical data.
  • To develop the Dengue Genographic Viewer (DGV) web service for visualizing DENV genotype distribution.
  • To enable DENV sequence analysis for serotype and genotype identification and geographical mapping.

Main Methods:

  • Collected publicly available DENV sequence data from the National Center for Biotechnology Information (NCBI).
  • Assigned genotype information to collected DENV sequences.
  • Developed the Dengue Genographic Viewer (DGV) with homology search functionality and integrated epidemiological data from Japan's Infectious Agents Surveillance Report (IASR).

Main Results:

  • A curated DENV database containing serotype, genotype, year, and country/region of collection was established.
  • The DGV web service visualizes the geographical distribution of DENV genotypes over specified time periods.
  • DGV can identify the serotype and genotype of user-submitted sequences and display related geographical and temporal data.

Conclusions:

  • The developed DENV database and DGV provide a valuable resource for understanding global DENV genotype distribution.
  • DGV facilitates the analysis of DENV outbreaks and the tracking of DENV-infected individuals entering Japan.
  • This overview of DENV genotype distribution can inform and enhance dengue infection control strategies.