Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

1.7K
Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
1.7K
Urinary Tract Calculi VI: Surgical Management01:25

Urinary Tract Calculi VI: Surgical Management

775
Procedures for Kidney StonesMedical intervention is necessary when kidney stones or renal calculi are too large to pass spontaneously (typically greater than 5 millimeters) when stones are accompanied by symptomatic infection (such as fever or pyelonephritis), when they impair kidney function, or when they cause persistent symptoms like severe pain, nausea, or urinary retention. Additionally, patients with only one kidney or those who cannot be treated with medical management also require...
775
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

718
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
718
Nephrons01:10

Nephrons

8.2K
The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
8.2K
Renal Corpuscle01:20

Renal Corpuscle

8.3K
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
8.3K
External Anatomy of the Kidney01:21

External Anatomy of the Kidney

4.5K
The kidneys are a pair of bean-shaped organs in the human body that play a critical role in maintaining overall health. They filter out waste products from the blood, regulate blood pressure, maintain electrolyte balance, and stimulate the production of red blood cells.
The kidneys are located in the retroperitoneal space on either side of the vertebral column, protected posteriorly by the 11th and 12th ribs. The right kidney sits slightly lower than the left owing to the presence of the liver...
4.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Identification of blood biomarkers of a healthy dietary pattern as facilitated by cluster analysis in patients from the MEDDINI study: a pilot randomised trial.

Journal of nutritional science·2026
Same author

Vutrisiran in Patients With Transthyretin Amyloidosis With Cardiomyopathy and Renal Impairment: Analyses From HELIOS-B.

Journal of cardiac failure·2026
Same author

Unraveling the impact of common medications on biomarker patterns in Alzheimer's disease and mild cognitive impairment.

Journal of Alzheimer's disease reports·2026
Same author

Salivary metabolomics for early detection of vascular contributions to cognitive impairment and dementia: Exploring microbiome dysbiosis and sex differences.

Journal of Alzheimer's disease : JAD·2026
Same author

Rapid and colorimetric assay for the detection of <i>S. pneumoniae</i> based on hydrogen peroxide release and analysis using color image processing.

The Analyst·2026
Same author

Distinct Metabolic Signatures Linked to High-Resolution Computed Tomography Radiographic Phenotypes in Stable and Progressive Fibrotic Lung Disease.

Metabolites·2026

Related Experiment Video

Updated: Mar 18, 2026

Unilateral Ureteral Obstruction Model for Investigating Kidney Interstitial Fibrosis
04:37

Unilateral Ureteral Obstruction Model for Investigating Kidney Interstitial Fibrosis

Published on: April 25, 2025

1.7K

Nonobstructive Acute Renal Failure with a Large Solitary Fibroid.

Rayan Elkattah1, Zineb Mashak1, Blakele Bakker1

  • 1Department of Obstetrics and Gynecology, University of Tennessee Chattanooga College of Medicine, Chattanooga, TN 37403, USA.

Case Reports in Obstetrics and Gynecology
|July 5, 2016
PubMed
Summary

Massive degenerating uterine fibroids can cause acute kidney injury due to elevated myoglobin levels. Surgical removal of the fibroid led to rapid improvement in renal function.

More Related Videos

Author Spotlight: Developing a Bedside Protocol for Kidney and Genitourinary Ultrasonography
03:19

Author Spotlight: Developing a Bedside Protocol for Kidney and Genitourinary Ultrasonography

Published on: June 21, 2024

2.6K
A Mouse Model to Evaluate the Long-Term Structural and Functional Outcomes after the Reversal of Prolonged Unilateral Ureteric Obstruction
05:34

A Mouse Model to Evaluate the Long-Term Structural and Functional Outcomes after the Reversal of Prolonged Unilateral Ureteric Obstruction

Published on: July 18, 2025

603

Related Experiment Videos

Last Updated: Mar 18, 2026

Unilateral Ureteral Obstruction Model for Investigating Kidney Interstitial Fibrosis
04:37

Unilateral Ureteral Obstruction Model for Investigating Kidney Interstitial Fibrosis

Published on: April 25, 2025

1.7K
Author Spotlight: Developing a Bedside Protocol for Kidney and Genitourinary Ultrasonography
03:19

Author Spotlight: Developing a Bedside Protocol for Kidney and Genitourinary Ultrasonography

Published on: June 21, 2024

2.6K
A Mouse Model to Evaluate the Long-Term Structural and Functional Outcomes after the Reversal of Prolonged Unilateral Ureteric Obstruction
05:34

A Mouse Model to Evaluate the Long-Term Structural and Functional Outcomes after the Reversal of Prolonged Unilateral Ureteric Obstruction

Published on: July 18, 2025

603

Area of Science:

  • Reproductive Endocrinology
  • Nephrology
  • Surgical Pathology

Background:

  • Uterine fibroids are common benign tumors, but can cause significant morbidity.
  • Acute kidney injury (AKI) in the context of abdominal pathology requires prompt diagnosis and management.
  • Elevated myoglobin levels can indicate muscle damage and may be associated with renal dysfunction.

Purpose of the Study:

  • To investigate the association between a degenerating fibroid uterus and nonobstructive acute renal failure.
  • To highlight myoglobinemia as a potential cause of AKI in this clinical scenario.

Main Methods:

  • Case presentation of a 38-year-old woman with acute abdominal pain and renal failure.
  • Laboratory evaluation including creatinine and myoglobin levels.
  • Surgical intervention via total abdominal hysterectomy for a large fibroid uterus.

Main Results:

  • The patient presented with elevated creatinine (3.9 mg/dL) and markedly elevated myoglobin (2140 ng/mL).
  • A 25 cm degenerating fibroid uterus was identified as the likely source.
  • Post-hysterectomy, serum myoglobin levels decreased, and renal function improved rapidly.

Conclusions:

  • Massive degenerating fibroids can lead to myoglobinemia.
  • Myoglobinemia is a potential cause of nonobstructive acute renal failure.
  • Surgical management of the fibroid resulted in resolution of AKI.