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Related Concept Videos

Next-generation Sequencing03:00

Next-generation Sequencing

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The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features....
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RNA-seq03:21

RNA-seq

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RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while...
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Multi-species Conserved Sequences02:51

Multi-species Conserved Sequences

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Next-generation sequencing technologies have created large genomic databases of a variety of animals and plants. Ever since the human genome project was completed, scientists studied the genome of primates, mammals, and other phylogenetically distant living beings. Such large-scale  studies have provided new insights into the evolutionary relationship between organisms.
Although the genome of each species varies greatly from each other, a few sequences are highly conserved. Such conserved...
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Related Experiment Video

Updated: Mar 18, 2026

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
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Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease

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Addressing Benefits, Risks and Consent in Next Generation Sequencing Studies.

R Meller1

  • 1Translational Stroke Program, Neuroscience Institute, Morehouse School of Medicine, Atlanta, USA.

Journal of Clinical Research & Bioethics
|July 5, 2016
PubMed
Summary

Genomic data sharing faces challenges balancing open access with patient privacy. DNA

Area of Science:

  • Genomics
  • Bioethics
  • Bioinformatics

Background:

  • Advances in DNA sequencing revolutionize genetic disorder diagnosis.
  • Open access to genomic data must align with human subject research principles.
  • Risks to patients in genomic studies are not fully understood.

Purpose of the Study:

  • To address challenges in balancing open access genomic data sharing with patient privacy.
  • To re-evaluate risks associated with genomic data sharing and establish new guidelines.
  • To examine conflicts between federal regulations and data sharing requirements for NIH-funded studies.

Main Methods:

  • Commentary on current ethical and regulatory frameworks for genomic data.
  • Analysis of de-identification strategies and their limitations.
Keywords:
ConsentGeneration sequencingHuman subject research

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Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies
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Last Updated: Mar 18, 2026

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  • Discussion of Big Data methodologies and re-identification risks.

    • Main Results:

    • De-identified genomic data can be re-identified through various databases.
    • DNA is an inherently identifying element, challenging traditional anonymity.
    • Current data security standards may not adequately protect patient identity in the future.

    Conclusions:

    • Existing data security standards are insufficient to guarantee patient anonymity.
    • New guidelines are needed for responsible genomic data sharing.
    • Federally funded investigators face complex ethical and regulatory hurdles.