Related Experiment Video
Updated: Mar 18, 2026
07:52
Remote Limb Ischemic Preconditioning: A Neuroprotective Technique in Rodents
Published on: June 2, 2015
12.8K
Perilipin 5 is protective in the ischemic heart
Christina Drevinge1, Knut T Dalen2, Maria Nastase Mannila3
1Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg and Sahlgrenska University Hospital, Gothenburg, Sweden; Wallenberg Laboratory, Institute of Medicine, University of Gothenburg and Sahlgrenska University Hospital, Gothenburg, Sweden.
International Journal of Cardiology
|July 5, 2016
Summary
Perilipin 5 (Plin5) plays a beneficial role in the heart during myocardial ischemia. Plin5 deficiency impairs cardiac lipid metabolism, leading to reduced function and survival in ischemic conditions.
Area of Science:
- Cardiovascular Biology
- Metabolic Research
Background:
- Myocardial ischemia alters cardiac metabolism, decreasing fatty acid oxidation and increasing lipid accumulation.
- The role of lipid droplet protein perilipin 5 (Plin5) in myocardial ischemia pathophysiology is not fully understood.
Purpose of the Study:
- To investigate how myocardial lipid content and dynamics affect ischemic heart function.
- To determine the role of perilipin 5 (Plin5) in the pathophysiology of myocardial ischemia.
Main Methods:
- Generated Plin5 knockout (Plin5-/-) mice to study the effects of Plin5 deficiency.
- Analyzed a human cohort with suspected coronary artery disease.
Main Results:
- Plin5 deficiency significantly reduced cardiac triglyceride content.
- Plin5-/- mice maintained normal heart function under normal conditions but showed reduced substrate availability, impaired function, and increased mortality during ischemia.
- A common polymorphism (rs884164) associated with reduced PLIN5 expression was linked to decreased heart function after ischemia in humans.
Conclusions:
- Plin5 deficiency alters cardiac lipid metabolism and is associated with reduced survival after myocardial ischemia.
- Plin5 plays a protective role in the ischemic heart.
Related Concept Videos
01:17Ischemic Heart Disease: Overview
3.8K
Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
3.8K
01:30Peripheral Artery Disease I: Introduction
568
Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
568
01:26Coronary Artery Disease IV: Preventive Measures
813
Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
813
01:27Coronary Artery Disease V: Interprofessional Care
373
Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...
373
01:27Peripheral Artery Disease III: Interprofessional Care
512
Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
512
01:20Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors
1.5K
Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
1.5K