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Therapeutic Effectiveness of Anticancer Phytochemicals on Cancer Stem Cells

Jisun Oh1, Lynn Hlatky2, Yong-Seob Jeong3

  • 1School of Food Science and Biotechnology (BK21 Plus), Kyungpook National University, Daegu 41566, Korea. j.oh@knu.ac.kr.

Toxins
|July 5, 2016
PubMed

Insights

Dietary phytochemicals show promise for cancer therapy by selectively targeting cancer stem cells (CSCs). This review explores how these compounds affect diverse cancer cell populations and CSCs specifically.

Area of Science:

  • Oncology
  • Cancer Biology
  • Pharmacology

Background:

  • Cancer stem cells (CSCs) are crucial for tumor growth and recurrence.
  • Targeting CSCs is a key strategy for effective cancer treatment.
  • Dietary phytochemicals possess anticancer properties and may selectively impact CSCs.

Purpose of the Study:

  • To review the influence of dietary phytochemicals on heterogeneous cancer cell populations.
  • To summarize the specific targeting of cancer stem cells (CSCs) by phytochemicals.
  • To highlight the therapeutic potential of phytochemicals in cancer treatment.

Main Methods:

  • Literature review of studies on phytochemicals and cancer cells.
  • Analysis of research on phytochemical effects on CSCs.
  • Synthesis of findings regarding phytochemicals' impact on cancer heterogeneity.

Main Results:

  • Phytochemicals demonstrate selective effects on cancer stem cells (CSCs) within heterogeneous populations.
  • Certain phytochemicals can inhibit CSC proliferation and survival.
  • Understanding these interactions can inform the development of novel cancer therapies.

Conclusions:

  • Dietary phytochemicals represent a promising avenue for developing targeted cancer therapies.
  • Selective targeting of CSCs by phytochemicals offers a strategy to overcome treatment resistance.
  • Further research into phytochemical mechanisms can lead to improved cancer prevention and treatment.
Keywords:
anticancercancercancer stem cellsphytochemicalspolyphenols

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