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Ring opening of epoxides with C-nucleophiles
Sadia Faiz1, Ameer Fawad Zahoor2
1Department of Chemistry, Government College University Faisalabad, Faisalabad, 38000, Pakistan.
Molecular Diversity
|July 5, 2016
Summary
This review details synthetic methods for epoxide ring opening using carbon nucleophiles. It covers key reactions from 1991 to 2015, highlighting versatile organic synthesis strategies.
Area of Science:
- Organic Chemistry
- Synthetic Chemistry
Background:
- Epoxides are reactive cyclic ethers, readily undergoing ring-opening reactions with nucleophiles.
- These reactions are fundamental in organic synthesis, producing diverse functionalized molecules.
Purpose of the Study:
- To review synthetic methodologies for epoxide ring opening.
- To focus specifically on reactions involving carbon nucleophiles.
- To cover literature published between 1991 and 2015.
Main Methods:
- Literature review of organic chemistry journals and databases.
- Analysis of synthetic strategies for epoxide ring opening with carbon nucleophiles.
- Categorization of methods based on nucleophile type and reaction conditions.
Main Results:
- Compilation of various synthetic routes for carbon nucleophile-mediated epoxide ring opening.
- Identification of key reaction classes and their applications.
- Overview of advancements in the field from 1991 to 2015.
Conclusions:
- Carbon nucleophile addition to epoxides offers a powerful route to diverse organic compounds.
- The reviewed period (1991-2015) shows significant developments in synthetic efficiency and scope.
- Understanding these synthetic approaches is crucial for modern organic synthesis.
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