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Biomimetic Immuno-Magnetosomes for High-Performance Enrichment of Circulating Tumor Cells
Ke Xiong1, Wei Wei2, Yongjie Jin1
1School of Life Science, Beijing Institute of Technology, Beijing, 100081, P. R. China.
Advanced Materials (Deerfield Beach, Fla.)
|July 5, 2016
Abstract:
A novel biomimetic immuno-magnetosome (IMS) is developed by coating a leukocyte membrane (decorated with anti-epithelial cell-adhesion molecule antibody) on a magnetic nanocluster. In addition to the good stability and magnetic controllability, the IMS also exhibits satisfactory binding avidity to circulating tumor cells but stealth property to leukocytes. As a result, rare tumor cells can be effectively enriched with undetectable leukocyte background.
