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BPD Following Preterm Birth: A Model for Chronic Lung Disease and a Substrate for ARDS in Childhood

Anita Bhandari1, Christopher Carroll2, Vineet Bhandari3

  • 1Division of Pediatric Pulmonology, Connecticut Children's Medical Center, University of Connecticut School of Medicine , Hartford, CT , USA.

Frontiers in Pediatrics
|July 6, 2016
PubMed

Insights

Pediatric acute respiratory distress syndrome (PARDS) may differ from adult ARDS. Bronchopulmonary dysplasia (BPD) may predispose infants to PARDS due to lung damage, with shared biomarkers indicating potential therapeutic targets.

Area of Science:

  • Pediatric Pulmonology
  • Critical Care Medicine
  • Neonatology

Background:

  • Pediatric acute respiratory distress syndrome (PARDS) may be distinct from adult ARDS.
  • A pediatric-specific definition is proposed, considering underlying lung/heart conditions.
  • Up to 13% of pediatric ARDS cases involve prematurity or chronic lung disease.

Purpose of the Study:

  • To investigate the role of bronchopulmonary dysplasia (BPD) in PARDS development.
  • To explore if BPD-damaged lungs serve as a substrate for PARDS.
  • To identify potential shared biomarkers between BPD and PARDS.

Main Methods:

  • Review of epidemiological data on PARDS and BPD.
  • Analysis of existing literature on biomarkers in BPD and ARDS.
  • Comparison of clinical symptomatology and outcomes.

Main Results:

  • Bronchopulmonary dysplasia (BPD) is the most common infant chronic lung disease.
  • BPD results in long-term lung damage affecting growth and immune function.
  • Shared biomarkers (KL-6, IL-6, IL-8, sICAM-1, angiopoietin-2, MMP-8, MMP-9) are associated with both BPD and ARDS.

Conclusions:

  • Damaged lungs from BPD may predispose children to PARDS.
  • Shared biomarkers suggest a potential link and common pathogenic pathways.
  • Recognizing unique PARDS patterns could guide targeted therapies.

Keywords:
BPDbiomarkerslung developmentlung diseasespediatric ARDS

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