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A Model of Disturbed Flow-Induced Atherosclerosis in Mouse Carotid Artery by Partial Ligation and a Simple Method of RNA Isolation from Carotid Endothelium
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Circulating miR-30 is related to carotid artery atherosclerosis

Yuqing Huang1, Jiyan Chen1, Yingling Zhou1

  • 1a Department of Cardiology , Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Disease, Guangdong General Hospital, Guangdong Academy of Medical Sciences, School of Medicine, South China University of Technology , Guangzhou , China.

Clinical and Experimental Hypertension (New York, N.Y. : 1993)
|July 6, 2016
PubMed

Insights

Lower levels of miR-30 were found in hypertensive patients and those with increased carotid intima-media thickness (CIMT). This suggests miR-30 may serve as a biomarker for atherosclerosis in hypertension.

Area of Science:

  • Cardiovascular Disease Research
  • Molecular Biology
  • Biomarker Discovery

Background:

  • Hypertension is a major risk factor for cardiovascular diseases, including atherosclerosis.
  • Carotid intima-media thickness (CIMT) is a marker of subclinical atherosclerosis.
  • MicroRNAs (miRNAs) are implicated in the pathogenesis of cardiovascular diseases.

Purpose of the Study:

  • To investigate the association between miR-30 expression and blood pressure parameters.
  • To evaluate the relationship of miR-30 with carotid intima-media thickness (CIMT).
  • To determine if miR-30 can serve as a biomarker for atherosclerosis in hypertensive patients.

Main Methods:

  • Quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) to measure miR-30 expression in 40 hypertensive patients and 40 controls.
  • Carotid artery ultrasonography to assess CIMT.
  • Office and ambulatory blood pressure monitoring.
  • Spearman correlation and logistic regression analyses to assess associations.

Main Results:

  • Hypertensive patients exhibited significantly lower miR-30 expression compared to healthy controls.
  • Lower miR-30 levels were also observed in individuals with increased CIMT.
  • miR-30 expression showed a significant negative correlation with 24-hour systolic blood pressure, 24-hour diastolic blood pressure, office systolic blood pressure, and CIMT.

Conclusions:

  • Circulating miR-30 levels are reduced in patients with essential hypertension and atherosclerosis.
  • miR-30 may function as a potential biomarker for identifying atherosclerosis in individuals with hypertension.
Abstract

Keywords:
Atherosclerosiscarotid intima-media thicknessessential hypertensionmiR-30

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