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Related Concept Videos

Enteric Nervous System: Regulation of GI Motor Activity01:11

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The neuronal supply to the gastrointestinal (GI) tract is essential for regulating various functions, including digestion, absorption, and movement of food. This intricate network of nerves is known as the enteric nervous system (ENS), often referred to as the "second brain" of the body.
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Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the...
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Related Experiment Video

Updated: Mar 18, 2026

Immunostaining to Visualize Murine Enteric Nervous System Development
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Postnatal Development of the Mouse Enteric Nervous System.

Jaime Pei Pei Foong1

  • 1Department of Physiology, University of Melbourne, Parkville, VIC, 3010, Australia. j.foong@unimelb.edu.au.

Advances in Experimental Medicine and Biology
|July 6, 2016
PubMed
Summary
This summary is machine-generated.

Postnatal development of the enteric nervous system (ENS) is influenced by environmental factors, not just genetics. Understanding these factors may help prevent motility disorders.

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Gastroenterology

Background:

  • Decades of research elucidated embryonic enteric nervous system (ENS) development.
  • Recent findings reveal significant postnatal ENS maturation.
  • Postnatal ENS development may be influenced by environmental factors, impacting motility disorders.

Purpose of the Study:

  • To review recent advances in postnatal murine ENS development.
  • To highlight potential environmental factors influencing ENS maturation.
  • To identify future research directions in this emerging field.

Main Methods:

  • Review of current literature on postnatal ENS development.
  • Focus on animal models, particularly murine models.
  • Analysis of genetic and environmental influences.

Main Results:

  • Significant ENS maturation occurs postnatally.
  • Environmental factors, alongside genetics, may regulate postnatal ENS development.
  • Mouse models are crucial for studying human enteric neuropathies.

Conclusions:

  • Postnatal ENS development is a critical area requiring further investigation.
  • Identifying environmental factors could lead to novel therapeutic strategies for motility disorders.
  • Future research should focus on elucidating the interplay between genetics and environment in postnatal ENS development.