Related Experiment Video
Updated: Mar 18, 2026

Author Spotlight: Network Pharmacology and Molecular Docking to Decipher the Action of Jiawei Shengjiang San Against Diabetic Kidney Disease
Published on: May 10, 2024
Antidiabetic potential of bioactive molecules coated chitosan nanoparticles in experimental rats
Venkatachalam Perumal1, Thiyagarajan Manickam2, Keuk-Soo Bang3
1Plant Genetic Engineering and Molecular Biology Lab, Department of Biotechnology, Periyar University, PeriyarPalkalai Nagar, Salem, 636 011, Tamil Nadu, India; Centre for Nanoscience and Nanotechnology, Periyar University, PeriyarPalkalai Nagar, Salem, 636 011, Tamil Nadu, India; Department of Biology, Western Kentucky University, Bowling Green, KY 42102, USA.
Abstract:
The present study was carried out to examine the antidiabetic effects of chitosan nanoparticles (CNPs) loaded with (Stevia rebaudiana leaf extract-SRLE) bioactive molecules in a rat model of streptozotocin (STZ) induced diabetes mellitus. Successful crosslinking of the bioactive molecules to the chitosan nanoparticles was confirmed by Fourier Transform Infrared Spectroscopy (FTIR). The colloidal characteristics of the synthesized nanoparticles were revealed by X-ray Diffraction (XRD) analysis. Morphological analysis by Transmission Electron Microscopy (TEM) revealed that thebioactive molecule-loaded CNPs were well-dispersed and spherical or polygonal in shape with an average size of<73.27nm than the z-average value (327nm) as measured by Dynamic Light Scattering (DLS). SRLE CNP-treated diabetic rats showed a significant reduction in their mean fasting blood glucose level compared with the diabetic control group. The serum levels of various enzymes viz., serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), alkaline phosphatases (ALP), lipid peroxidation, and antioxidant such as catalase (CAT), reduced glutathione (GSH), and superoxide dismutase (SOD) in the SRLE CNP-treated group were closer to normal levels than those in the diabetic control group.
Related Concept Videos
Oral Hypoglycemic Agents: α-Glucosidase Inhibitors
Acarbose and miglitol are...
Dipeptidyl Peptidase 4 Inhibitors
Oral Hypoglycemic Agents: Glinides
Oral Hypoglycemic Agents: Biguanides and Glitazones
Glucagon-like Receptor Agonists
GLP-1, when administered in high doses intravenously, triggers insulin secretion, inhibits glucagon release, slows gastric emptying, reduces food intake, and restores normal insulin secretion. However, its rapid inactivation by...

