Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

4.1K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
4.1K
Epigenetic Regulation01:46

Epigenetic Regulation

34.2K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
34.2K
Chromatin Modification in iPS Cells01:32

Chromatin Modification in iPS Cells

2.3K
Chromatin modification alters gene expression; therefore, scientists can add histone-modifying enzymes, histone variants, and chromatin remodeling complexes to somatic cells to aid reprogramming into pluripotent stem (iPS) cells.
Compact chromatin makes reprogramming difficult. Enzymes, such as histone demethylases and acetyltransferases, are often added during reprogramming to loosen the chromatin, making the DNA more accessible to transcription factors. Molecules that inhibit histone...
2.3K
Histone Modification02:32

Histone Modification

16.9K
The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone...
16.9K
Spreading of Chromatin Modifications02:25

Spreading of Chromatin Modifications

9.9K
The histone proteins in the nucleosomes are post-translationally modified (PTM) to increase or decrease access to DNA. The commonly observed PTMs are methylation, acetylation, phosphorylation, and ubiquitination of lysine amino acids in the histone H3 tail region. These histone modifications have specific meaning for the cell. Hence, they are called "histone code". The protein complex involved in histone modification is termed as "reader-writer" complex.
Writers
The writer...
9.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Polarity and anti-distortive polarons in WO<sub>3</sub> through epitaxial shear strain.

Nature communications·2026
Same author

Association of miR-146a/b and miR-181a with Chronic Obstructive Pulmonary Disease.

Biochemical genetics·2026
Same author

Repeated Acute Reductions Do Not Equal Chronic Control: Interpreting the Magnitude of Apheresis effects of Lp(a).

European journal of preventive cardiology·2026
Same author

Evidence Mapping of ctDNA Reporting in Pancreatic Ductal Adenocarcinoma: Toward a Shared Quantitative Language for ctDNA.

Cancers·2026
Same author

Evaluation of Th1-Th2 balance in patients with recurrent implantation failure; a systematic review and meta-analysis.

BMC immunology·2026
Same author

PdNeuRAM: forming-free, multi-bit Pd/HfO<sub>2</sub> ReRAM for energy-efficient neuromorphic computing.

Communications engineering·2026

Related Experiment Video

Updated: Mar 18, 2026

Author Spotlight: Novel Assay for Studying B-Cell Responses in Multiple Sclerosis Research
05:55

Author Spotlight: Novel Assay for Studying B-Cell Responses in Multiple Sclerosis Research

Published on: December 1, 2023

1.4K

Epigenetic Modifications and Therapy in Multiple Sclerosis.

Saeed Aslani1, Naser Jafari2, Mohammad Reza Javan3

  • 1Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Neuromolecular Medicine
|July 8, 2016
PubMed
Summary

Epigenetics, heritable gene function changes without altering DNA sequence, plays a role in autoimmune diseases like multiple sclerosis (MS). Understanding epigenetic dysregulation offers potential for novel MS therapies targeting DNA methylation and histone modifications.

Keywords:
Environmental factorsEpigenetic regulationEpigenetic therapyMultiple sclerosis

More Related Videos

Induction and Diverse Assessment Indicators of Experimental Autoimmune Encephalomyelitis
06:19

Induction and Diverse Assessment Indicators of Experimental Autoimmune Encephalomyelitis

Published on: September 9, 2022

4.8K
Author Spotlight: Creating a Versatile Experimental Autoimmune Encephalomyelitis Model Relevant for Both Male and Female Mice
05:44

Author Spotlight: Creating a Versatile Experimental Autoimmune Encephalomyelitis Model Relevant for Both Male and Female Mice

Published on: October 13, 2023

2.6K

Related Experiment Videos

Last Updated: Mar 18, 2026

Author Spotlight: Novel Assay for Studying B-Cell Responses in Multiple Sclerosis Research
05:55

Author Spotlight: Novel Assay for Studying B-Cell Responses in Multiple Sclerosis Research

Published on: December 1, 2023

1.4K
Induction and Diverse Assessment Indicators of Experimental Autoimmune Encephalomyelitis
06:19

Induction and Diverse Assessment Indicators of Experimental Autoimmune Encephalomyelitis

Published on: September 9, 2022

4.8K
Author Spotlight: Creating a Versatile Experimental Autoimmune Encephalomyelitis Model Relevant for Both Male and Female Mice
05:44

Author Spotlight: Creating a Versatile Experimental Autoimmune Encephalomyelitis Model Relevant for Both Male and Female Mice

Published on: October 13, 2023

2.6K

Area of Science:

  • Neuroimmunology
  • Genetics
  • Epigenetics

Background:

  • Genetic studies like GWAS have advanced understanding of autoimmune disease (AID) etiology, but precise causes remain elusive.
  • Non-genetic factors are crucial for AID susceptibility, as evidenced by incomplete concordance in identical twins.
  • Epigenetics, heritable gene function alterations without DNA sequence changes, involves DNA methylation, histone modifications, and microRNA regulation.

Purpose of the Study:

  • To review recent advancements in understanding the association between epigenetics and multiple sclerosis (MS) pathogenesis.
  • To explore the potential of epigenetic modifications as therapeutic targets for MS.

Main Methods:

  • Review of current literature on epigenetic alterations in MS.
  • Analysis of epigenetic mechanisms potentially linking environmental factors to genetic predisposition in MS.
  • Identification of enzymes controlling epigenetic modifications as potential therapeutic targets.

Main Results:

  • Emerging evidence suggests epigenetic changes are involved in the initiation and progression of MS.
  • Epigenetic modifications may bridge environmental risk factors with genetic susceptibility in MS.
  • Inhibiting enzymes like DNA methyltransferases and histone deacetylases shows promise for MS treatment.

Conclusions:

  • Epigenetic dysregulations are implicated in the pathogenesis of MS.
  • Targeting epigenetic modifications presents a promising therapeutic avenue for MS.
  • Further research into epigenetic mechanisms is crucial for developing effective MS therapies.