Related Experiment Video
Updated: Mar 18, 2026
Author Spotlight: Enhancing Cerebral Ischemia Research with a Simplified Rat Model
Published on: July 5, 2024
Neuroprotective Effectiveness of Intravenous Ubiquinone in Rat Model of Irreversible Cerebral Ischemia
M A Belousova1, O G Tokareva2, E A Gorodetskaya2
1Fundamental Medicine Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia. margarita.a.belousova@gmail.com.
Abstract:
The neuroprotective effect of ubiquinone (coenzyme Q10)was demonstrated on the rats model of ischemic stroke provoked by persistent 24-h occlusion of the middle cerebral artery. Coenzyme Q10 (30 mg/kg) was injected intravenously in 60 min after artery occlusion. Ubiquinone crossed the blood-brain barrier, accumulated in the brain, and produced a neuroprotective effect: it alleviated ischemia-induced neurological deficit and reduced the size of necrotic zone by 49% in comparison with rats receiving physiological saline.
