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Updated: Mar 18, 2026

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues
Published on: June 3, 2019
Cardiac Autonomic Drive during Arterial Hypertension and Metabolic Disturbances
S I Kseneva1, E V Borodulina2, O Yu Trifonova2
1E.D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia. viksbest@mail.ru.
Abstract:
ANS support of the cardiac work was assessed with analysis of heart rate variability in representative samples of patients with arterial hypertension and metabolic disturbances manifested by overweight, classes I-II obesity, compromised glucose tolerance, and type II diabetes. Initially enhanced sympathetic effects on the heart rate demonstrated no further increase during the orthostatic test in contrast to suprasegmentary influences enhanced by this test. The pronouncedness of revealed peculiarities in ANS drive to the heart correlated with metabolic disturbances, and these peculiarities attained maximum in patients with type II diabetes.
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