Related Experiment Video
Updated: Mar 18, 2026
07:07
A Novel Scalp Acupuncture-based Method to Target the Hand Motor Hotspot for Non-invasive Brain Stimulation
Published on: December 19, 2025
290
Frontal Fibrosing Alopecia and Increased Scalp Sweating: Is Neurogenic Inflammation the Common Link?
Matthew J Harries1, Sharon Wong2, Paul Farrant3
1Dermatology Centre, University of Manchester, Salford Royal NHS Foundation Trust, Salford, UK.
Skin Appendage Disorders
|July 8, 2016
Summary
Frontal fibrosing alopecia (FFA) is a scarring hair loss condition. This study explores a potential link between FFA and increased scalp sweating, possibly due to local inflammation.
Area of Science:
- Dermatology
- Trichology
- Human Physiology
Background:
- Frontal fibrosing alopecia (FFA) is an uncommon scarring alopecia.
- FFA presents as frontal hairline recession and eyebrow loss.
- An association with increased scalp sweating in FFA patients is noted.
Purpose of the Study:
- To investigate the co-occurrence of increased scalp sweating in patients with frontal fibrosing alopecia.
- To explore potential pathophysiological mechanisms linking FFA and hyperhidrosis.
Main Methods:
- Case series presentation of patients with FFA and associated scalp sweating.
- Discussion of potential biological mechanisms for the observed association.
Main Results:
- Patients with frontal fibrosing alopecia reported increased sweating localized to the scalp.
- The study observed a correlation between FFA and hyperhidrosis of the scalp.
Conclusions:
- The increased sweating in FFA patients may stem from the local inflammatory process.
- Hypotheses include a local axonal sweating reflex or neuropeptide modulation of sweat glands.
Related Concept Videos
01:16Accessory Structures of the Skin: Hair and Hair Follicles
5.3K
Hair and hair follicles are integral components of the integumentary system. Hair is a filamentous structure composed mainly of a protein called keratin. It is found on the surface of the skin throughout the body, except for areas such as the palms of the hands and soles of the feet.
Hair is a keratinous filament growing out of the epidermis. It is primarily made of dead, keratinized cells. Hair strands originate at the epidermal penetration called the hair follicle. The hair shaft is the part...
Hair is a keratinous filament growing out of the epidermis. It is primarily made of dead, keratinized cells. Hair strands originate at the epidermal penetration called the hair follicle. The hair shaft is the part...
5.3K
01:18Disorders of the Autonomic Nervous System
1.8K
The autonomic nervous system (ANS) is an intricate network of nerves that controls functions such as the regulation of heart rate, digestion, and blood pressure regulation. When this system malfunctions, it can lead to various disorders that affect multiple bodily functions. One common feature of many autonomic disorders is the involvement of smooth blood vessels, which play a crucial role in regulating blood flow throughout the body.
Raynaud's disease, also known as Raynaud's...
Raynaud's disease, also known as Raynaud's...
1.8K
01:23Skin Diseases and Disorders
6.1K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
6.1K
01:21Accessory Structures of the Skin: Sebaceous Glands
5.2K
A sebaceous gland is a type of oil gland found almost all over the skin ( except palms and soles) and helps lubricate and waterproof the skin and hair. Most sebaceous glands are associated with hair follicles. They generate and excrete sebum, a mixture of lipids, onto the skin surface, thereby naturally lubricating the dry and dead layer of keratinized cells of the stratum corneum, keeping it pliable.
These glands that produce the oils on the skin and hair are holocrine glands. The mature...
These glands that produce the oils on the skin and hair are holocrine glands. The mature...
5.2K
01:19Psychoneuroimmunology: Diabetes and Cancer
598
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
598