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Updated: Mar 18, 2026

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
A Total Synthesis of Paeoveitol
Lun Xu1, Fengyi Liu1, Li-Wen Xu1
1Key Laboratory of Applied Surface and Colloid Chemistry of MOE & School of Chemistry and Chemical Engineering Shaanxi Normal University , 620 West Chang'an Ave, Xi'an, 710119, China.
Abstract:
A four-step total synthesis of paeoveitol (1), a recently disclosed norditerpene natural product from Paeonia vetchii, is reported. This highly concise synthetic route was guided by biosynthetic considerations and enabled by an unusual intermolecular ortho-quinone methide [4 + 2]-cycloaddition reaction, which proceeded with excellent regio- and diastereoselectivity. Density functional theory (DFT) calculations point to a crucial intermolecular hydrogen bond and π-π stacking interaction that govern selectivity in this process.
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