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Porcine In Vivo Validation of a Virtual Contrast Model: The Influence of Contrast Agent Properties and Vessel Flow
T W Peach1, Y Ventikos2, J V Byrne3
1From the Department of Mechanical Engineering (T.W.P., Y.V.), University College London, London, UK.
AJNR. American Journal of Neuroradiology
|July 9, 2016
Summary
Accurate computational fluid dynamics (CFD) modeling of contrast transport aids aneurysm treatment prediction. This study found parent vessel flow rate, not contrast properties, significantly impacts contrast decay in aneurysms.
Area of Science:
- Biomedical Engineering
- Medical Imaging
- Computational Fluid Dynamics
Background:
- Computational fluid dynamics (CFD) simulations are crucial for predicting aneurysm treatment outcomes.
- Modeling angiographic contrast transport is key to validating these CFD simulations.
- Understanding contrast dynamics aids in evaluating treatment efficacy.
Purpose of the Study:
- To investigate the influence of flow rate and contrast properties on in silico predictions of aneurysm contrast residence and decay.
- To assess the accuracy of CFD models in predicting contrast transport in experimental aneurysms.
Main Methods:
- Created four experimental sidewall aneurysms in swine.
- Observed contrast flow patterns and decay rates using angiography.
- Developed a CFD model from 3D angiography to predict contrast residence.
- Simulated the impact of contrast viscosity, density, and blood flow rate on contrast residence.
Main Results:
- CFD model accurately predicted contrast infiltration and washout patterns.
- Contrast decay rate was underestimated by approximately 25% in initial simulations.
- Parent vessel flow rate was identified as the sole cause of the underestimation.
- Contrast viscosity and density had negligible effects on decay rate.
- A linear correlation was observed between parent vessel flow rate and contrast decay rate.
Conclusions:
- Contrast fluid properties (viscosity, density) have a negligible effect on modeled contrast decay rates in experimental sidewall aneurysms.
- A strong linear correlation exists between parent vessel flow rate and contrast decay within physiological ranges.
- Accurate estimation of parent vessel flow rate is critical for reliable CFD predictions of contrast dynamics in aneurysms.
