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Updated: Aug 15, 2026

Syntheses, Crystallization, and Spectroscopic Characterization of 3,5-Lutidine N-Oxide Dehydrate
Published on: April 24, 2018
Access to Pyrazolidin-3,5-diones through Anodic N-N Bond Formation
Tile Gieshoff1,2, Dieter Schollmeyer1, Siegfried R Waldvogel3,4
1Institute of Organic Chemistry, Duesbergweg 10-14, 55128, Mainz, Germany.
Abstract:
Pyrazolidin-3,5-diones are important motifs in heterocyclic chemistry and are of high interest for pharmaceutical applications. In classic organic synthesis, the hydrazinic moiety is installed through condensation using the corresponding hydrazine building blocks. However, most N,N'-diaryl hydrazines are toxic and require upstream preparation owing to their low commercial availability. We present an alternative and sustainable synthetic approach to pyrazolidin-3,5-diones that employs readily accessible dianilides as precursors, which are anodically converted to furnish the N-N bond. The electroconversion is conducted in a simple undivided cell under constant-current conditions.
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