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Related Experiment Video

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High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities
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[Not Available].

Antoine F Villa1, Huan Tran Hong1, Hwee Min Lee1

  • 1Centre antipoison de Paris, Hôpital Fernand Widal, Paris, France.

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|July 10, 2016
PubMed
Summary
This summary is machine-generated.

Indoramin poisoning can cause prolonged QTc intervals and seizures, even with delayed effects. Medical resuscitation and 24-hour cardiac monitoring are recommended for indoramin overdose.

Keywords:
ECG changesQTacute poisoningconvulsionsdrug induced long QT syndromedysrhythmiasindoraminindoramineintoxication aiguëmodifications ECGoverdoseseizuressurdosagesyndrome QT d’origine médicamenteusetorsades de pointestroubles du rythme

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Area of Science:

  • Pharmacology
  • Clinical Toxicology
  • Cardiology

Context:

  • Retrospective analysis of indoramin-only poisoning cases from 1986-2010.
  • Data collected from the Paris Poison Centre.
  • Inclusion of 55 cases (40 adults, 15 children).

Purpose:

  • To investigate the clinical manifestations and outcomes of indoramin self-poisoning.
  • To determine the dose-dependent cardiac effects of indoramin.
  • To establish recommendations for managing indoramin overdose.

Summary:

  • Mean ingested dose was 701mg±464mg.
  • 30% of patients exhibited prolonged QTc intervals (≥0.50s), with the lowest observed dose being 625mg.
  • Two cases of seizures were reported after ingesting 900mg and 2250mg, with delayed cardiac effects up to 18 hours noted in literature.

Impact:

  • Highlights the risk of cardiac arrhythmias and seizures associated with indoramin overdose.
  • Suggests the need for prompt medical intervention and extended cardiac monitoring (≥24 hours) for significant indoramin ingestions.
  • Informs clinical practice guidelines for managing indoramin poisoning.