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High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities
Published on: November 15, 2013
48.7K
[Not Available]
Pascale De Calbiac1, Fabien Lamoureux1, Xavier Pourrat1
1Laboratoire d'analyses et de contrôle qualité, Pharmacie Logipôle Trousseau, CHU de Tours, Tours, France.
Therapie
|July 10, 2016
Summary
Antibiotic stability in portable pumps is crucial for treating cystic fibrosis bronchial superinfections. Piperacillin concentration significantly decreased at 35°C, necessitating careful pump use and cold packs.
Area of Science:
- Pharmacology
- Drug Stability
- Medical Devices
Context:
- Limited data exists on antibiotic stability in portable infusion pumps.
- Real-world use involves temperatures up to 35°C.
Purpose:
- To review existing antibiotic stability data in portable pumps.
- To assess the stability of piperacillin/tazobactam at 35°C.
Summary:
- Piperacillin concentration decreased by up to 33% in portable pumps at 35°C.
- Tazobactam concentration remained stable during the study.
- Findings highlight potential issues with piperacillin stability during infusion.
Impact:
- Informs prescribers and patients about antibiotic stability limitations.
- Recommends using cold accumulators and limiting infusion to 24 hours.
- Guides future research on antibiotic stability in portable pumps.
