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Related Experiment Video

Updated: Mar 18, 2026

High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities

High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities

Published on: November 15, 2013

[Not Available].

Françoise Goirand¹, Bernard Royer², Anne Hulin³

¹Laboratoire de Pharmacologie et Toxicologie, CHU Dijon, France.

|July 10, 2016

Summary

This summary is machine-generated.

Therapeutic drug monitoring for everolimus (a drug preventing transplant rejection) is recommended. While a target trough concentration (C0) of 3-8 μg/L is proposed, only the lower limit is supported by evidence.

Keywords:

everolimus level of evidence monitoring niveau de preuve suivi thérapeutique et pharmacologique therapeutic drug évérolimus

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Last Updated: Mar 18, 2026

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Area of Science:

Pharmacology
Transplantation Medicine
Clinical Pharmacy

Context:

Everolimus is used to prevent rejection in adult de novo renal and cardiac transplant recipients.
It is typically administered with ciclosporine and corticosteroids.
Therapeutic drug monitoring (TDM) with a target trough concentration (C0) of 3-8 μg/L has been suggested.

Purpose:

To systematically review the literature and determine the level of recommendation for everolimus TDM.
To evaluate the evidence supporting the proposed target C0 range.

Summary:

Everolimus displays significant interindividual pharmacokinetic variability and a weak dose-exposure relationship.
A strong correlation exists between C0 values and overall drug exposure (AUC).
While C0 > 3 μg/L is linked to reduced rejection rates, the upper limit of 8 μg/L lacks formal validation. No trials compare TDM with standard care.

Impact:

The current evidence supports a recommendation for everolimus monitoring.
Further research is needed to validate the upper C0 limit and explore alternative monitoring strategies.
This review informs clinical practice regarding optimal everolimus dosing and monitoring.