Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

High-Performance Liquid Chromatography: Types of Detectors01:15

High-Performance Liquid Chromatography: Types of Detectors

1.5K
The role of the detectors in High-Performance Liquid Chromatography (HPLC) is to analyze the solutes as they exit from the chromatographic column. The detector recognizes the solute's property and generates corresponding electrical signals, which are converted into a readable graph of the detector's response versus elution time called a chromatogram at the computer. There are several types of HPLC detectors, each with its own advantages and limitations, depending on the analyte...
1.5K
Qualitative Analysis01:10

Qualitative Analysis

1.3K
Qualitative analysis is the process of identifying elements, ions, or compounds in an unknown sample. It is the first and most fundamental type of analysis based on the hierarchy of analytical goals. This hierarchy is significant as it provides a structured approach to scientific research, with qualitative analysis serving as the initial step, providing essential information before moving on to quantitative or other forms of analysis.
There are two main approaches to qualitative analysis:...
1.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Deltamethrin Placental Transfer and Seasonal Pyrethroid Exposure: A Mother-Newborn Dyad Pilot Study.

Therapeutic drug monitoring·2026
Same author

Human serum albumin profiling by top-down analysis enables multi-class liver fibrosis staging: a cross-platform validation study.

Scientific reports·2026
Same author

Advances in organ-on-chip for drug transporter study: Key insights and hurdles.

Drug metabolism and disposition: the biological fate of chemicals·2026
Same author

Mapping the human chemical exposome for public health.

Nature medicine·2026
Same author

Assessing Lead Exposure by Biological Matrices Analysis and Links to Breast Cancer: A Critical Review of Experimental and Epidemiological Findings.

European journal of breast health·2025
Same author

Toxicology of Heavy Metals in Biological Matrices: A Paradigm Shift From Single-Analyte Measurement to Comprehensive Screening.

Therapeutic drug monitoring·2025

Related Experiment Video

Updated: Jan 13, 2026

Color Spot Test As a Presumptive Tool for the Rapid Detection of Synthetic Cathinones
06:06

Color Spot Test As a Presumptive Tool for the Rapid Detection of Synthetic Cathinones

Published on: February 5, 2018

26.1K

Detecting the Undetectable: Analytical Strategies for Novel Psychoactive Substances.

Elisa Jousselin1, Pauline Griffeuille1,2, Isy Petit1

  • 1Pharmacology and Transplantation, Inserm U1248, Université de Limoges, Limoges, France.

Therapeutic Drug Monitoring
|January 9, 2026
PubMed
Summary
This summary is machine-generated.

Detecting novel psychoactive substances (NPS) is challenging. An integrated analytical approach using advanced mass spectrometry and artificial intelligence (AI) enhances toxicological surveillance and public health protection.

Keywords:
analytical surveillanceartificial intelligenceforensic toxicologyhigh-resolution mass spectrometrynovel psychoactive substances

More Related Videos

Rapid High-throughput Species Identification of Botanical Material Using Direct Analysis in Real Time High Resolution Mass Spectrometry
11:14

Rapid High-throughput Species Identification of Botanical Material Using Direct Analysis in Real Time High Resolution Mass Spectrometry

Published on: October 2, 2016

12.1K
High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry
10:17

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry

Published on: April 23, 2019

10.2K

Related Experiment Videos

Last Updated: Jan 13, 2026

Color Spot Test As a Presumptive Tool for the Rapid Detection of Synthetic Cathinones
06:06

Color Spot Test As a Presumptive Tool for the Rapid Detection of Synthetic Cathinones

Published on: February 5, 2018

26.1K
Rapid High-throughput Species Identification of Botanical Material Using Direct Analysis in Real Time High Resolution Mass Spectrometry
11:14

Rapid High-throughput Species Identification of Botanical Material Using Direct Analysis in Real Time High Resolution Mass Spectrometry

Published on: October 2, 2016

12.1K
High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry
10:17

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry

Published on: April 23, 2019

10.2K

Area of Science:

  • Analytical Chemistry
  • Forensic Toxicology
  • Public Health Surveillance

Background:

  • Novel psychoactive substances (NPS) present analytical challenges due to structural diversity and low concentrations.
  • Limited availability of certified reference materials hinders accurate detection.
  • This review addresses analytical strategies and innovative technologies for NPS surveillance.

Purpose of the Study:

  • To review current and emerging analytical strategies for detecting NPS.
  • To evaluate innovative technologies for toxicological surveillance of NPS.
  • To highlight the role of advanced techniques in addressing NPS challenges.

Main Methods:

  • Systematic review of chromatographic, spectrometric, ambient ionization, and AI-assisted methods.
  • Emphasis on applicability, sensitivity, and adaptability in clinical, forensic, and environmental settings.
  • Analysis of conventional and high-resolution techniques, alongside emerging AI applications.

Main Results:

  • Conventional methods are limited to known compounds; advanced techniques offer broader detection but are resource-intensive.
  • Artificial intelligence (AI) shows promise for untargeted screening and early compound identification.
  • Emerging tools like molecular networking and wastewater-based epidemiology enhance real-time monitoring.

Conclusions:

  • An integrated framework combining high-resolution mass spectrometry, ambient ionization, and AI is crucial for the evolving NPS landscape.
  • Standardization of reference materials and interdisciplinary collaboration are key to improving NPS detection speed and sensitivity.
  • Enhanced analytical capabilities are vital for public health protection against emerging substances.