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Related Experiment Video

Updated: Mar 18, 2026

High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities

High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities

Published on: November 15, 2013

[Not Available].

Aida Khaled¹, Myriam Ben Hamida¹, Faten Zeglaoui¹

¹Service de Dermatologie, Hôpital Charles Nicolle, Tunis, Tunisie.

|July 10, 2016

Summary

This summary is machine-generated.

Methotrexate effectively treats severe psoriasis, achieving high remission rates and long-term disease control in Tunisian patients. Lower doses demonstrated significant efficacy and good tolerance, offering a viable treatment option.

Keywords:

methotrexate méthotrexate psoriasis therapy traitement

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Last Updated: Mar 18, 2026

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Area of Science:

Dermatology
Pharmacology

Context:

Severe psoriasis affects a significant portion of the population.
Treatment options for severe psoriasis are continuously being evaluated for efficacy and safety.

Purpose:

To evaluate the efficacy and tolerance of methotrexate in Tunisian patients with severe psoriasis.
To assess long-term remission rates and identify potential toxicities associated with methotrexate treatment.

Summary:

A retrospective study of 21 Tunisian patients with severe psoriasis treated with oral methotrexate.
High complete (62%) and partial (28.5%) remission rates were observed.
Methotrexate demonstrated good tolerance with low rates of hematological and hepatic toxicities (9.5%).

Impact:

Methotrexate is an effective treatment for severe psoriasis, even at lower doses than typically reported.
The study highlights the potential for long-term remission and favorable outcomes in patients with severe psoriasis.
Findings support the use of methotrexate as a valuable therapeutic option for managing severe psoriasis.