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A New Method for Inducing a Depression-Like Behavior in Rats
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Social functioning in major depressive disorder.

Aleksandra Kupferberg1, Lucy Bicks2, Gregor Hasler3

  • 1Division of Molecular Psychiatry, Translational Research Center, University Hospital of Psychiatry University of Bern, Switzerland.

Neuroscience and Biobehavioral Reviews
|July 11, 2016
PubMed
Summary
This summary is machine-generated.

Depression significantly impacts social functioning, affecting affiliation, communication, and perception. Understanding these social deficits is key to improving depression diagnosis and treatment.

Keywords:
CompetitionCooperationDepressionEconomic gamesMDDPrisoner’ dilemmaRDoCSocial functioningSocial interactionSocial mediaSocial rejectionTOMUltimatum game

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Social Psychology

Background:

  • Depression is linked to social risk factors, impairments, and poor functioning.
  • The National Institute of Mental Health's Research Domain Criteria (RDoC) 'Systems for Social Processes' provides a framework for understanding these deficits.
  • Social factors play a crucial role in the development and outcomes of depression.

Purpose of the Study:

  • To provide an overview of social aspects associated with depression using the RDoC 'Systems for Social Processes' framework.
  • To explore the bio-psycho-social interplay of impaired social behaviors in depression.
  • To discuss the diagnostic specificity and implications of social deficits in depression.

Main Methods:

  • Review and synthesis of existing research on social processes in depression.
  • Application of the RDoC 'Systems for Social Processes' framework.
  • Examination of social deficits at behavioral, neuroanatomical, neurochemical, and genetic levels, including animal models.

Main Results:

  • Impaired affiliation and attachment (e.g., social anhedonia, rejection sensitivity).
  • Impaired social communication (e.g., emotion recognition, cooperation).
  • Impaired social perception (e.g., empathy deficits, theory-of-mind deficits).
  • Impact on social networks and social media use.
  • Dysfunctional social processes examined across multiple levels of analysis.

Conclusions:

  • Social deficits are integral to depression's pathogenesis and consequences.
  • Research on social processes in depression can enhance diagnostic assessments and treatment strategies.
  • Findings have implications for both diagnostic and transdiagnostic approaches to depression.