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Published on: May 21, 2019
An acid-cleavable phthalocyanine tetramer as an activatable photosensitiser for photodynamic therapy
Sun Y S Chow1, Pui-Chi Lo2, Dennis K P Ng1
1Department of Chemistry, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China. dkpn@cuhk.edu.hk.
Abstract:
An acetal-linked self-quenched zinc(ii) phthalocyanine tetramer has been prepared. In an acidic environment in phosphate buffered saline or inside tumour cells, the phthalocyanine units of the tetramer are separated thereby restoring the fluorescence emission and singlet oxygen production. This response enables this compound to serve as a promising activatable photosensitiser for photodynamic therapy.
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