Associations between osteoporosis and coronary artery disease in postmenopausal women
1a Department of Internal Medicine , St. Vincent's Hospital, The Catholic University of Korea , Suwon , South Korea ;
Insights
Osteoporosis is linked to coronary artery disease (CAD) in postmenopausal women. Low bone density was associated with higher rates of coronary artery calcium and obstructive CAD, independent of age and risk factors.
Area of Science:
- Cardiovascular Health
- Bone Metabolism
- Geriatric Medicine
Background:
- Coronary artery disease (CAD) and osteoporosis are significant health concerns for postmenopausal women.
- These conditions contribute substantially to mortality and morbidity in this demographic.
Purpose of the Study:
- To investigate the association between osteoporosis and CAD in asymptomatic postmenopausal women.
- To determine if osteoporosis is an independent risk factor for CAD in this population.
Main Methods:
- Included 863 asymptomatic postmenopausal women without prior cardiovascular disease.
- Assessed bone mineral density (BMD) using dual-energy X-ray absorptiometry.
- Evaluated coronary artery disease (CAD) severity via multidetector computed tomography.
Main Results:
- Low BMD (osteopenia and osteoporosis) correlated with older age, lower BMI, and diabetes.
- Higher incidences of significant coronary artery calcium (≥100), obstructive CAD, and multivessel disease were observed in women with low BMD.
- Osteoporosis remained significantly associated with high coronary artery calcium score and obstructive CAD after adjusting for age and cardiovascular risk factors.
Conclusions:
- Osteoporosis is independently associated with high coronary artery calcium score and obstructive coronary artery disease in asymptomatic postmenopausal women.
- Multidetector computed tomography effectively revealed these associations.
- Findings suggest a potential link between bone health and cardiovascular health in postmenopausal women.
Objective:
Coronary artery disease (CAD) and osteoporosis are major causes of mortality and morbidity in postmenopausal women. We aimed to investigate the association between osteoporosis and CAD in asymptomatic postmenopausal women at a single center.
Methods:
This study included 863 postmenopausal women without histories of cardiovascular diseases who visited the Health Promotion Center from June 1, 2004 to May 31, 2015. All subjects were screened for bone mineral density (BMD) by dual-energy X-ray absorptiometry and for the degree of CAD by multidetector computed tomography.
Results:
Low BMD including osteopenia and osteoporosis was found to be significantly associated with old age, low body mass index, and a higher prevalence of diabetes mellitus. The incidences of CAD including a high coronary artery calcium score (≥100), obstructive coronary artery disease, and multivessel disease were significantly higher in subjects with low BMD. After adjusting for age and cardiovascular risk factors, osteoporosis was associated with a high coronary artery calcium score (p = 0.015) and with obstructive coronary artery disease (p = 0.002). There was a trend toward significance with multivessel disease (p = 0.052).
Conclusions:
High coronary artery calcium score and obstructive coronary artery disease, as revealed by multidetector computed tomography, were associated with osteoporosis in asymptomatic postmenopausal women, independent of cardiovascular risk factors and age.
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