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Cycloplegic effect of atropine compared with cyclopentolate-tropicamide combination in children with hypermetropia

Rabi Yahaya Sani1, Sadiq Hassan1, Saudat Garba Habib1

  • 1Department of Ophthalmology, Faculty of Clinical Sciences, College of Health Sciences, Bayero University/Aminu Kano Teaching Hospital, Kano, Nigeria.

Nigerian Medical Journal : Journal of the Nigeria Medical Association
|July 12, 2016
PubMed

Insights

A combination of cyclopentolate and tropicamide offers a viable alternative to atropine for cycloplegic refraction in children with hypermetropia, providing similar results with potentially fewer side effects.

Area of Science:

  • Ophthalmology
  • Pediatric Ophthalmology
  • Optometry

Background:

  • Cycloplegic refraction is crucial for diagnosing hypermetropia in children.
  • Atropine, while effective, has a prolonged action and significant side effects.
  • Shorter-acting cycloplegic agents are preferred for pediatric use.

Purpose of the Study:

  • To compare the efficacy of atropine 1% with a combination of cyclopentolate 1% and tropicamide 1% for cycloplegic refraction.
  • To evaluate the cycloplegic effect of these agents in children diagnosed with hypermetropia.

Main Methods:

  • A crossover interventional study was conducted on 63 children (126 eyes) aged 5-12 years with hypermetropia.
  • Two cycloplegic refraction regimens were administered: atropine 1% and cyclopentolate 1% with tropicamide 1%.
  • Data were analyzed using SPSS v22.0, with P ≤ 0.05 considered significant.

Main Results:

  • No statistically significant difference was found in the mean spherical equivalent values between atropine 1% and the cyclopentolate/tropicamide combination for both right (P=0.59) and left eyes (P=0.56).
  • Mean spherical equivalent for the right eye was 4.73 ± 2.1 DS (atropine) vs. 4.54 ± 1.9 DS (combination).
  • Mean spherical equivalent for the left eye was 4.74 ± 2.0 DS (atropine) vs. 4.54 ± 1.8 DS (combination).

Conclusions:

  • The combination of 1% cyclopentolate and 1% tropicamide is an effective alternative to 1% atropine for cycloplegic refraction in pediatric hypermetropia.
  • This combination may offer a more favorable side effect profile compared to atropine.
  • Further research could explore long-term outcomes and patient tolerance.
Abstract

Keywords:
Atropinecyclopentolatecycloplegic refractionhypermetropiatropicamide

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