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Updated: Mar 18, 2026

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Published on: June 2, 2014
Rare Complications of Migraine With Aura
1Norton Headache and Concussion Center, Norton Neuroscience Institute, Louisville, KY, USA.. brian.plato@nortonhealthcare.org.
Purpose:
To provide a review of the diagnostic criteria, pathophysiology, and potential treatments of the complications of migraine as identified by the International Classification of Headache Disorders 3β, with the exception of status migrainosus.
Method:
Migraine with aura may be associated with the onset of rare, but significantly disabling neurological symptoms. This review provides an overview of the associated complications that may arise from migraine with aura.
Conclusion:
The complications of migraine that arise from migraine aura are infrequently encountered in clinical practice; however, they can be severely disabling for patients. As these conditions are encountered, thorough diagnostic evaluation is necessary. In some cases, it may be difficult to find a consistently reliable therapeutic option for these patients; however, as more cases enter the literature, a greater understanding of these conditions and how to treat them may arise.
Insights
Migraine with aura can cause rare but disabling neurological complications. Early diagnosis and understanding treatment options are crucial for managing these severe, infrequently encountered conditions.
Area of Science:
- Neurology
- Headache Medicine
Background:
- Migraine with aura is associated with rare neurological complications.
- These complications can be significantly disabling for patients.
Purpose of the Study:
- To review diagnostic criteria for migraine complications (excluding status migrainosus).
- To explore the pathophysiology and potential treatments of these complications, as defined by the International Classification of Headache Disorders 3β.
Main Methods:
- Literature review focusing on rare neurological symptoms associated with migraine with aura.
- Analysis of diagnostic criteria, pathophysiology, and treatment strategies.
Main Results:
- Complications of migraine with aura are infrequently seen in clinical practice.
- These conditions can lead to severe patient disability.
Conclusions:
- Thorough diagnostic evaluation is essential when these complications are encountered.
- Finding reliable therapeutic options can be challenging, but ongoing research may improve understanding and treatment.
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