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Updated: Mar 18, 2026
FISH for Pre-implantation Genetic Diagnosis
Published on: February 23, 2011
[PRENATAL DIAGNOSIS: EVOLUTION OF CLINICAL INDICATIONS AND THE SOCIETY IN THE PAST 30 YEARS]
Insights
Prenatal diagnosis methods have evolved since 1979, adapting to demographic shifts and improving detection of chromosomal abnormalities with less invasive procedures. This technological advancement optimizes prenatal care, saving resources and preventing fetal loss.
Area of Science:
- Obstetrics and Gynecology
- Medical Genetics
- Public Health
Context:
- Prenatal diagnosis services at Hospital Universitario Ramón y Cajal from 1979 to 2010.
- Analysis of screening and diagnostic methodologies, clinical indications, and demographic changes.
- Longitudinal study tracking the evolution of prenatal care practices.
Purpose:
- To establish parallels between prenatal diagnostic methodologies, clinical indications, and demographic shifts.
- To demonstrate the impact of technological evolution on prenatal diagnosis.
- To analyze how screening and diagnostic methods have adapted to population changes.
Summary:
- Reports on prenatal diagnosis results from 1979-2010, highlighting changes in clinical indications.
- Shows how evolving screening and diagnostic technologies influenced these changes.
- Documents the adaptation of prenatal diagnosis to demographic trends over three decades.
Impact:
- Enabled more effective prenatal diagnosis through precise clinical indications.
- Facilitated detection of chromosomal abnormalities using less invasive procedures.
- Optimized prenatal diagnosis, saving resources, personnel, and reducing unnecessary fetal losses.
Abstract:
Here we report the results of prenatal diagnosis at the Hospital Universitario Ramón y Cajal since its opening in 1979 to 2010, establishing a parallelism between the different methodologies for screening and prenatal diagnosis, clinical indications, and demographic changes. It shows how the indications have varied as to the structure of the population did. These changes have been possible thanks to the fact that the screening and prenatal diagnosis methods have allowed it. Demonstrating, once again, how procedures evolve with technology and adapt to the demography. This evolution has allowed to make a more effective prenatal diagnosis because the clinical indications have been more precise what has allowed to detect the same number of fetuses with chromosomal abnormalities by performing less invasive procedures, which has led to an optimization of prenatal diagnosis saving resources and personnel and, above all, avoiding unnecessary fetal losses.
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